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- W1968346712 abstract "New experimental evidence supports theidea that future therapeutic strategies fortreating cardiovascular disease could tar-get sites within the brain. Our recentstudy demonstrates the existence of previ-ously unrecognized central nervousβ-adrenoceptor (β-AR) mechanisms,blockade of which has a beneficial effecton the failing heart. It has been assumedthat β-AR antagonists (β-blockers) have adirect favorable influence on the heart,but our results challenge this view, sug-gesting that β-blockers may also actdirectly in the brain and that this actioncould contribute to their clinical effect-iveness in heart failure. These data add toan increasing body of evidence support-ing the idea that novel approaches mightbe found to treat cardiovascular disease byaiming at sites within the CNS.Heart failure (HF) is one of the mostimportant public health problems. Mor-bidity and mortality associated with HFremain high, despite considerable achieve-ments in its treatment. Analysis of recentclinical trials indicates similar, or possiblysuperior, beneficial effects of β-AR block-ade in comparison to angiotensin-convert-ing enzyme (ACE) inhibition. In fact, thechoice of ACE inhibitors as first-line ther-apy in patients with HF has recently beenquestioned" @default.
- W1968346712 created "2016-06-24" @default.
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- W1968346712 date "2008-08-01" @default.
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- W1968346712 title "β-blockers: acting in the brain but healing the heart" @default.
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- W1968346712 doi "https://doi.org/10.1586/14779072.6.7.913" @default.
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