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- W1968351120 abstract "Background: The incremental role of bedside tissue Doppler echocardiography and B‐type natriuretic peptide (BNP) over the clinical judgment has been recently reported in the emergency diagnosis of congestive heart failure with a normal left ventricular ejection fraction (HFNEF). However, how well does this diagnostic strategy be applicable in the setting of atrial fibrillation is unknown. Objective: To investigate the usefulness of bedside tissue Doppler echocardiography and BNP in the emergency diagnosis of HFNEF in elderly patients with permanent, nonvalvular atrial fibrillation. Methods: Forty‐one consecutive elderly patients with an ejection fraction ≥50% (mean age 84 years; 22 with HFNEF and 19 with noncardiac cause), hospitalized for acute dyspnea at rest, were prospectively enrolled; bedside septal E/Ea and BNP were obtained at admission. Results: By multivariable logistic regression analysis including the clinical judgment of heart failure, E/Ea and BNP, E/Ea (P = 0.014) and BNP (P = 0.018) provided independent diagnostic information. Optimal cutoffs were 13 for E/Ea (area under the ROC curve of 0.846, P < 0.0001; sensitivity 81.8%, specificity 89.5%) and 253 pg/ml for BNP (area under the ROC curve of 0.928, P < 0.0001; sensitivity 86.4%, specificity 89.5%). The concordance between the clinical judgment and BNP concentration at the cutoff of 253 pg/ml correctly classified 24 of 25 patients; E/Ea at the cutoff of 13 correctly classified 14 of the 16 patients with discrepancy. Conclusion: Bedside tissue Doppler echocardiography and BNP provide useful additional diagnostic information over the clinical judgment for the emergency diagnosis of HFNEF in elderly patients with permanent, nonvalvular atrial fibrillation." @default.
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- W1968351120 date "2007-02-28" @default.
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- W1968351120 title "Usefulness of Bedside Tissue Doppler Echocardiography and B-Type Natriuretic Peptide (BNP) in Differentiating Congestive Heart Failure from Noncardiac Cause of Acute Dyspnea in Elderly Patients with a Normal Left Ventricular Ejection Fraction and Permanent, Nonvalvular Atrial Fibrillation: Insights from a Prospective, Monocenter Study" @default.
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- W1968351120 doi "https://doi.org/10.1111/j.1540-8175.2007.00418.x" @default.
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