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• W1968358640 abstract "Background: Ustekinumab is a fully human IgG1 monoclonal antibody that blocks the biologic activity of interleukin-12/23. Ustekinumab is approved for treatment of plaque psoriasis and has been shown to be effective for induction and maintenance of clinical response in anti-TNF resistant Crohn's disease (CD). The aim of the study was to describe the real-life experience with open-label use of ustekinumab in anti-TNF resistant CD patients. Methods: A retrospective observational open-label study. Clinical response was defined by physician's global assessment combined with decision to continue therapy. The clinical response was evaluated at 3, 6, 12 months and last follow-up. Results: Thirty-eight patients were included in the study. Initial clinical response was achieved in 28/38 (73.7%) of the patients. Among the initial responders, 80% with follow-up data maintained their response for 6 months. At 12 months of follow-up, 88.9% of patients responding at 6 months maintained their response. At the last follow-up (7.9 ± 5.2 mo) 27/38 (71%) of the patients were responding, and 73.3% were able to discontinue corticosteroids. Dose escalation was required in 47.7% of the patients and was successful in 61.1% of them. Summary: In this real-life cohort of severe anti-TNF resistant CD, an initial clinical response to subcutaneous ustekinumab was observed in 73.7% of the patients. The initial response was successfully maintained in the majority of patients for up to 12 months. Subcutaneous ustekinumab is an effective therapeutic option in this challenging patient cohort. The optimal dosing and injection schedule remain to be established in future studies." @default.
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• W1968358640 date "2014-11-01" @default.
• W1968358640 modified "2023-10-14" @default.
• W1968358640 title "Subcutaneous ustekinumab for the treatment of anti-TNF resistant Crohn's disease—The McGill experience" @default.
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• W1968358640 doi "https://doi.org/10.1016/j.crohns.2014.06.005" @default.
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