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- W1968360469 endingPage "737" @default.
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- W1968360469 abstract "Multidrug ABC transporters such as the human multidrug resistance P-glycoprotein (ABCB1) play an important role in the extrusion of drugs from the cell and their overexpression can be a cause of failure of anticancer and antimicrobial chemotherapy. These transport systems contain two nucleotide-binding domains (NBDs) where ATP is bound and hydrolyzed and two membrane domains (MDs) which mediate vectorial transport of substrates across the cell membrane. Recent crystal structures of the bacterial ABCB1 homologues Sav1866 from Staphylococcus aureus and MsbA from Salmonella typhimurium and other organisms shed light on the possible conformational states adopted by multidrug ABC transporters during transport. These structures help to interpret cellular and biochemical data gathered on these transport proteins over the past three decades. However, there are contradictory views on how the catalytic cycle of ATP binding and hydrolysis by the NBDs is linked to the change in drug binding affinity at the MDs, which underlies the capture (high affinity) of the transported drug on one side of the membrane and its release (low affinity) on the other. This review provides an overview of the current evidence for the different transport models and establishes the most recent structure-function relationships in multidrug ABC transporters." @default.
- W1968360469 created "2016-06-24" @default.
- W1968360469 creator A5009619552 @default.
- W1968360469 creator A5086591800 @default.
- W1968360469 date "2009-05-01" @default.
- W1968360469 modified "2023-09-25" @default.
- W1968360469 title "Molecular basis of multidrug transport by ABC transporters" @default.
- W1968360469 cites W124504601 @default.
- W1968360469 cites W1487748486 @default.
- W1968360469 cites W1549517261 @default.
- W1968360469 cites W1591356314 @default.
- W1968360469 cites W1719045946 @default.
- W1968360469 cites W1776236658 @default.
- W1968360469 cites W1821679912 @default.
- W1968360469 cites W1893057187 @default.
- W1968360469 cites W1927723646 @default.
- W1968360469 cites W1964828092 @default.
- W1968360469 cites W1965250838 @default.
- W1968360469 cites W1967105053 @default.
- W1968360469 cites W1968769447 @default.
- W1968360469 cites W1969008019 @default.
- W1968360469 cites W1969609100 @default.
- W1968360469 cites W1969999093 @default.
- W1968360469 cites W1973876121 @default.
- W1968360469 cites W1974652764 @default.
- W1968360469 cites W1976490116 @default.
- W1968360469 cites W1977994192 @default.
- W1968360469 cites W1980637520 @default.
- W1968360469 cites W1981109070 @default.
- W1968360469 cites W1981146802 @default.
- W1968360469 cites W1981388811 @default.
- W1968360469 cites W1981893537 @default.
- W1968360469 cites W1982003972 @default.
- W1968360469 cites W1982917248 @default.
- W1968360469 cites W1983739049 @default.
- W1968360469 cites W1983764349 @default.
- W1968360469 cites W1983956828 @default.
- W1968360469 cites W1986401262 @default.
- W1968360469 cites W1987641460 @default.
- W1968360469 cites W1989178650 @default.
- W1968360469 cites W1990456014 @default.
- W1968360469 cites W1992764122 @default.
- W1968360469 cites W1994265289 @default.
- W1968360469 cites W1994348363 @default.
- W1968360469 cites W1995375922 @default.
- W1968360469 cites W1998428612 @default.
- W1968360469 cites W2001258946 @default.
- W1968360469 cites W2003576920 @default.
- W1968360469 cites W2006439869 @default.
- W1968360469 cites W2006700952 @default.
- W1968360469 cites W2008330611 @default.
- W1968360469 cites W2008349463 @default.
- W1968360469 cites W2008935282 @default.
- W1968360469 cites W2010099401 @default.
- W1968360469 cites W2010689523 @default.
- W1968360469 cites W2013068322 @default.
- W1968360469 cites W2015800304 @default.
- W1968360469 cites W2016846828 @default.
- W1968360469 cites W2016848332 @default.
- W1968360469 cites W2017491613 @default.
- W1968360469 cites W2019063268 @default.
- W1968360469 cites W2020084384 @default.
- W1968360469 cites W2021253110 @default.
- W1968360469 cites W2021934932 @default.
- W1968360469 cites W2022000951 @default.
- W1968360469 cites W2023467195 @default.
- W1968360469 cites W2023695537 @default.
- W1968360469 cites W2023703396 @default.
- W1968360469 cites W2026984793 @default.
- W1968360469 cites W2027718963 @default.
- W1968360469 cites W2030756202 @default.
- W1968360469 cites W2033202752 @default.
- W1968360469 cites W2035506170 @default.
- W1968360469 cites W2037136453 @default.
- W1968360469 cites W2037258070 @default.
- W1968360469 cites W2037302753 @default.
- W1968360469 cites W2037518670 @default.
- W1968360469 cites W2038118611 @default.
- W1968360469 cites W2041364548 @default.
- W1968360469 cites W2043266311 @default.
- W1968360469 cites W2048213764 @default.
- W1968360469 cites W2049265997 @default.
- W1968360469 cites W2049885064 @default.
- W1968360469 cites W2050037298 @default.
- W1968360469 cites W2050563271 @default.
- W1968360469 cites W2051511646 @default.
- W1968360469 cites W2055634974 @default.
- W1968360469 cites W2056367481 @default.
- W1968360469 cites W2058530636 @default.
- W1968360469 cites W2059354565 @default.
- W1968360469 cites W2061600887 @default.
- W1968360469 cites W2062133534 @default.
- W1968360469 cites W2063623087 @default.
- W1968360469 cites W2065677310 @default.
- W1968360469 cites W2067337225 @default.
- W1968360469 cites W2069161621 @default.
- W1968360469 cites W2069382823 @default.
- W1968360469 cites W2071950147 @default.