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• W1968363456 abstract "Interferon-gamma is known to play a complex modulatory role in immune defence during microbial infections. Its actions in pneumococcal meningitis, however, remain ill-defined. Here, a pathological role for IFN-γ was demonstrated using a murine model of pneumococcal meningitis, in that C57BL/6J mice deficient in this pro-inflammatory cytokine (IFN-γ(-/-)) showed less severe acute and long-term neuropathology following intracerebral challenge with Streptococcus pneumoniae. The absence of IFN-γ significantly lengthened the survival of mice that otherwise would have developed fatal clinical signs within two days of CNS infection. Compared to their wild-type counterparts, IFN-γ(-/-) mice showed a diminished inflammatory response (attenuated levels of pro-inflammatory cytokines in the cerebrospinal fluid) and milder brain pathologies (less BBB permeability to protein and brain haemorrhage) during the acute phase of disease. Following a full regime of antibiotic treatment, we found substantial brain injuries in the wild-type mice 10days after infection. IFN-γ(-/-) mice, however, showed decreased neuronal damage in both hippocampus and cortex. In the longer term (≈10weeks p.i.), the wild-type mice that had survived meningitis due to antibiotic treatment had neurobehavioural abnormalities including diurnal hypoactivity, nocturnal hyperactivity and impaired performance in a discrimination reversal task. IFN-γ(-/-) mice, concomitantly tested in the automated IntelliCage platform, had reduced behavioural and cognitive disorders compared to wild-type mice. Both IFN-γ(-/-) and wild-type survivors of pneumococcal meningitis showed impaired working memory in the IntelliCage-based complex patrolling task. These observations indicate an association between IFN-γ-driven acute brain pathology and the long-term neurological sequelae resulting from pneumococcal meningitis." @default.
• W1968363456 created "2016-06-24" @default.
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• W1968363456 date "2014-08-01" @default.
• W1968363456 modified "2023-10-16" @default.
• W1968363456 title "The pro-inflammatory cytokine interferon-gamma is an important driver of neuropathology and behavioural sequelae in experimental pneumococcal meningitis" @default.
• W1968363456 cites W1571481062 @default.
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• W1968363456 cites W1970720793 @default.
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• W1968363456 cites W1989369404 @default.
• W1968363456 cites W1990914734 @default.
• W1968363456 cites W1991490575 @default.
• W1968363456 cites W1991808761 @default.
• W1968363456 cites W1993220836 @default.
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• W1968363456 cites W2001026746 @default.
• W1968363456 cites W2006124128 @default.
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• W1968363456 cites W2045281478 @default.
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• W1968363456 cites W2077137971 @default.
• W1968363456 cites W2077828570 @default.
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• W1968363456 cites W2108054631 @default.
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• W1968363456 doi "https://doi.org/10.1016/j.bbi.2014.02.020" @default.
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• W1968363456 hasPublicationYear "2014" @default.
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