FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968365871> ?p ?o ?g. }

• W1968365871 endingPage "322" @default.
• W1968365871 startingPage "315" @default.
• W1968365871 abstract "Previous studies have demonstrated that treatment with 17beta-estradiol (E(2)) improves both spatial and nonspatial memory in young female mice. Still unclear, however, are the molecular mechanisms underlying the beneficial effects of E(2) on memory. We have previously demonstrated that a single post-training intraperitoneal (i.p.) injection of 0.2 mg/kg E(2) can enhance hippocampal-dependent spatial and object memory consolidation (e.g., Gresack & Frick, 2006b). Therefore, in the present study, we performed a microarray analysis on the dorsal hippocampi of 4-month-old female mice injected i.p. with vehicle or 0.2 mg/kg E(2). Genes were considered differentially expressed following E(2) treatment if they showed a greater than 2-fold change in RNA expression levels compared to controls. Overall, out of a total of approximately 25,000 genes represented on the array, 204 genes showed altered mRNA expression levels upon E(2) treatment, with 111 up-regulated and 93 down-regulated. Of these, 17 of the up-regulated and 6 of the down-regulated genes are known to be involved in learning and memory. mRNA expression changes in 5 of the genes were confirmed by real-time quantitative PCR analysis, and protein changes in these same genes were confirmed by Western blot analysis: Hsp70, a heat shock protein known to be estrogen responsive; Igfbp2, an IGF-I binding protein; Actn4, an actin binding protein involved in protein trafficking; Tubb2a, the major component of microtubules; and Snap25, a synaptosome-specific protein required for neurotransmitter release. The types of genes altered indicate that E(2) may induce changes in the structural mechanics of cells within the dorsal hippocampus that could be conducive to promoting memory consolidation." @default.
• W1968365871 created "2016-06-24" @default.
• W1968365871 creator A5039942880 @default.
• W1968365871 creator A5059285417 @default.
• W1968365871 date "2009-03-01" @default.
• W1968365871 modified "2023-10-18" @default.
• W1968365871 title "The effects of acute 17β-estradiol treatment on gene expression in the young female mouse hippocampus" @default.
• W1968365871 cites W1507423369 @default.
• W1968365871 cites W1846766371 @default.
• W1968365871 cites W1890987893 @default.
• W1968365871 cites W1928820616 @default.
• W1968365871 cites W1965758172 @default.
• W1968365871 cites W1968196184 @default.
• W1968365871 cites W1969110511 @default.
• W1968365871 cites W1970257032 @default.
• W1968365871 cites W1972049807 @default.
• W1968365871 cites W1973320610 @default.
• W1968365871 cites W1979965363 @default.
• W1968365871 cites W1983069981 @default.
• W1968365871 cites W1984572492 @default.
• W1968365871 cites W1989470426 @default.
• W1968365871 cites W1990150167 @default.
• W1968365871 cites W1993777290 @default.
• W1968365871 cites W1994630618 @default.
• W1968365871 cites W1994639132 @default.
• W1968365871 cites W1995175293 @default.
• W1968365871 cites W1997750064 @default.
• W1968365871 cites W2002090514 @default.
• W1968365871 cites W2003982930 @default.
• W1968365871 cites W2004912639 @default.
• W1968365871 cites W2005139532 @default.
• W1968365871 cites W2005602845 @default.
• W1968365871 cites W2006594678 @default.
• W1968365871 cites W2008172722 @default.
• W1968365871 cites W2016387138 @default.
• W1968365871 cites W2016977783 @default.
• W1968365871 cites W2022531767 @default.
• W1968365871 cites W2027010243 @default.
• W1968365871 cites W2032679733 @default.
• W1968365871 cites W2033569758 @default.
• W1968365871 cites W2034627732 @default.
• W1968365871 cites W2036479534 @default.
• W1968365871 cites W2036504185 @default.
• W1968365871 cites W2036698947 @default.
• W1968365871 cites W2040174711 @default.
• W1968365871 cites W2042355949 @default.
• W1968365871 cites W2044561443 @default.
• W1968365871 cites W2044819723 @default.
• W1968365871 cites W2045035263 @default.
• W1968365871 cites W2048310604 @default.
• W1968365871 cites W2048937021 @default.
• W1968365871 cites W2050390944 @default.
• W1968365871 cites W2052035818 @default.
• W1968365871 cites W2054659813 @default.
• W1968365871 cites W2056382418 @default.
• W1968365871 cites W2056695794 @default.
• W1968365871 cites W2059601159 @default.
• W1968365871 cites W2060233351 @default.
• W1968365871 cites W2064200220 @default.
• W1968365871 cites W2065875615 @default.
• W1968365871 cites W2068972835 @default.
• W1968365871 cites W2073461969 @default.
• W1968365871 cites W2074667468 @default.
• W1968365871 cites W2074751399 @default.
• W1968365871 cites W2081797127 @default.
• W1968365871 cites W2081848351 @default.
• W1968365871 cites W2089092547 @default.
• W1968365871 cites W2091395024 @default.
• W1968365871 cites W2094905802 @default.
• W1968365871 cites W2095325806 @default.
• W1968365871 cites W2100106314 @default.
• W1968365871 cites W2108529838 @default.
• W1968365871 cites W2109137609 @default.
• W1968365871 cites W2109557436 @default.
• W1968365871 cites W2118573957 @default.
• W1968365871 cites W2119641064 @default.
• W1968365871 cites W2124539062 @default.
• W1968365871 cites W2130632811 @default.
• W1968365871 cites W2131266318 @default.
• W1968365871 cites W2132977458 @default.
• W1968365871 cites W2158223072 @default.
• W1968365871 cites W2161695527 @default.
• W1968365871 cites W2163837911 @default.
• W1968365871 cites W2169308317 @default.
• W1968365871 cites W2332515736 @default.
• W1968365871 cites W301898889 @default.
• W1968365871 cites W2034354612 @default.
• W1968365871 doi "https://doi.org/10.1016/j.nlm.2008.09.017" @default.
• W1968365871 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2674265" @default.
• W1968365871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18938255" @default.
• W1968365871 hasPublicationYear "2009" @default.
• W1968365871 type Work @default.
• W1968365871 sameAs 1968365871 @default.
• W1968365871 citedByCount "38" @default.
• W1968365871 countsByYear W19683658712012 @default.
• W1968365871 countsByYear W19683658712013 @default.
• W1968365871 countsByYear W19683658712014 @default.
• W1968365871 countsByYear W19683658712015 @default.

• next