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- W1968366571 abstract "Endovanilloids are defined as endogenous ligands of the transient receptor potential vanilloid type 1 (TRPV1) protein, a nonselective cation channel that belongs to the large family of TRP ion channels, and is activated by the pungent ingredient of hot chilli peppers, capsaicin. TRPV1 is expressed in some nociceptor efferent neurons, where it acts as a molecular sensor of noxious heat and low pH. However, the presence of these channels in various regions of the central nervous system, where they are not likely to be targeted by these noxious stimuli, suggests the existence of endovanilloids. Three different classes of endogenous lipids have been found recently that can activate TRPV1, i.e. unsaturated N‐acyldopamines, lipoxygenase products of arachidonic acid and the endocannabinoid anandamide with some of its congeners. To classify a molecule as an endovanilloid, the compound should be formed or released in an activity‐dependent manner in sufficient amounts to evoke a TRPV1‐mediated response by direct activation of the channel. To control TRPV1 signaling, endovanilloids should be inactivated within a short time‐span. In this review, we will discuss, for each of the proposed endogenous ligands of TRPV1, their ability to act as endovanilloids in light of the criteria mentioned above." @default.
- W1968366571 created "2016-06-24" @default.
- W1968366571 creator A5007484138 @default.
- W1968366571 creator A5066586472 @default.
- W1968366571 date "2004-04-27" @default.
- W1968366571 modified "2023-10-17" @default.
- W1968366571 title "Endovanilloids. Putative endogenous ligands of transient receptor potential vanilloid 1 channels" @default.
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- W1968366571 doi "https://doi.org/10.1111/j.1432-1033.2004.04081.x" @default.
- W1968366571 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15128293" @default.
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