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- W1968370407 abstract "Thymus and lymph nodes from the A.TL recombinant line were utilized as sources of responding cells in MLR (mixed lymphocyte response) assays to MHC-determined (major histocompatibility complex) antigenic differences. Cells from both sources were stimulated to proliferate by antigenic determinants controlled by the H-2K region alone, H-2D region and the H-2I-H-2S regions. Nylon-fiber-adherent splenic cells from each of the stimulating cell strains stimulated T-cell-dependent responses. Synergistic interactions between A.TL thymus and lymph node cells were initiated by antigenic products limited to single H-2 regions. Antigenic differences determined within the H-2I region were not required for synergistic responses to H-2K-controlled products or for the generation of cytotoxic killer cells to H-2D-associated antigens. The H-2I-region-associated products also were very effective in stimulating T-cell synergy. These data demonstrate that the two responsive T-cell subpopulations can both be stimulated by alloantigens coded within a single known H-2 region." @default.
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- W1968370407 date "1976-01-01" @default.
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- W1968370407 title "Synergistic interactions between lymph node and thymus cells in response to antigenic differences limited to selected regions of the H-2 complex" @default.
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- W1968370407 doi "https://doi.org/10.1016/0008-8749(76)90333-6" @default.
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