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• W1968370892 abstract "Genetics-based personalized approaches to pain management have received a setback because of the nonreproducibility of functional genetic associations such as the pain-modulatory effect of the catechol-O-methyl transferase (COMT) gene 472G>A single-nucleotide polymorphism. Given that many of the pain-relevant genetic variants are common (allelic frequencies of 10-50%), we hypothesized that a major reason for difficulties in reproducing demonstrations of genetic influences on pain is the concomitant presence in a single individual of several functional genetic polymorphisms that act as confounders." @default.
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• W1968370892 date "2008-06-11" @default.
• W1968370892 modified "2023-10-14" @default.
• W1968370892 title "The Consequence of Concomitantly Present Functional Genetic Variants for the Identification of Functional Genotype–Phenotype Associations in Pain" @default.
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• W1968370892 doi "https://doi.org/10.1038/clpt.2008.103" @default.
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