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• W1968372287 endingPage "346" @default.
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• W1968372287 abstract "Non-coding RNAs (ncRNAs) and their associated regulatory networks are increasingly being implicated in mediating a complex repertoire of neurobiological functions. Cognitive and behavioral processes are proving to be no exception. In this review, we discuss the emergence of many novel, diverse and rapidly expanding classes and subclasses of short and long ncRNAs. We briefly review the life cycles and molecular functions of these ncRNAs. We also examine how ncRNA circuitry mediates brain development, plasticity, stress responses and aging, and highlight its potential roles in the pathophysiology of cognitive disorders, including neural developmental and age-associated neurodegenerative diseases, as well as those that manifest throughout the lifespan. Non-coding RNAs (ncRNAs) and their associated regulatory networks are increasingly being implicated in mediating a complex repertoire of neurobiological functions. Cognitive and behavioral processes are proving to be no exception. In this review, we discuss the emergence of many novel, diverse and rapidly expanding classes and subclasses of short and long ncRNAs. We briefly review the life cycles and molecular functions of these ncRNAs. We also examine how ncRNA circuitry mediates brain development, plasticity, stress responses and aging, and highlight its potential roles in the pathophysiology of cognitive disorders, including neural developmental and age-associated neurodegenerative diseases, as well as those that manifest throughout the lifespan. genomic DNA wrapped around histone protein octamers (i.e. nucleosomes), non-histone proteins and associated factors forming a compact ‘beads-on-a-string’ structure that is dynamically rearranged within the cell nucleus in an environmentally responsive manner. macromolecular assemblies of enzymes and associated factors that read, write and execute chromatin regulatory programs such as post-translational modifications of histone proteins, repositioning of nucleosomes and altering higher-order chromatin structure (e.g. entire chromosomal regions). highly interrelated and environmentally responsive molecular processes including DNA methylation, histone and chromatin modifications, ncRNA deployment, RNA editing and nuclear reorganization that are responsible for regulating genomic structure and function and for establishing and maintaining metastable cellular memory states (e.g. profiles of gene transcription, imprinting and X chromosome inactivation). diverse classes of RNA molecules not translated into proteins that possess intricate regulatory and structural functions. molecular components associated with ncRNA biogenesis and function (e.g. RBPs and Argonaute proteins), diversification (e.g. RNA editing enzymes) and intracellular (e.g. molecular motors) and extracellular trafficking (e.g. gap junctions, exosomes and systemic RNA receptors)." @default.
• W1968372287 created "2016-06-24" @default.
• W1968372287 creator A5007635759 @default.
• W1968372287 creator A5011709863 @default.
• W1968372287 date "2011-06-01" @default.
• W1968372287 modified "2023-10-03" @default.
• W1968372287 title "Non-coding RNA networks underlying cognitive disorders across the lifespan" @default.
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