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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968372807> ?p ?o ?g. }

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• W1968372807 abstract "We have used mRNA differential display PCR to search for genes induced in activated T cells and have found the LGALS1 (lectin, galactoside-binding, soluble) gene to be strongly up-regulated in effector T cells. The protein coded by the LGALS1 gene is a β-galactoside-binding protein (βGBP), which is released by cells as a monomeric negative growth factor but which can also associate into homodimers (galectin-1) with lectin properties. Northern blot analysis revealed that ex vivo isolated CD8+ effector T cells induced by a viral infection expressed high amounts of LGALS1 mRNA, whereas LGALS1 expression was almost absent in resting CD8+ T cells. LGALS1 expression could be induced in CD4+ and CD8+ T cells upon activation with the cognate peptide antigen and high levels of LGALS1 expression were found in concanavalin A-activated T cells but not in lipopolysaccharide-activated B cells. Gel filtration and Western blot analysis revealed that only monomeric βGBP was released by activated CD8+ T cells and in vitro experiments further showed that recombinant βGBP was able to inhibit antigen-induced proliferation of naive and antigen-experienced CD8+ T cells. Thus, these data indicate a role of βGBP as an autocrine negative growth factor for CD8+ T cells." @default.
• W1968372807 created "2016-06-24" @default.
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• W1968372807 date "1998-08-01" @default.
• W1968372807 modified "2023-09-27" @default.
• W1968372807 title "β-Galactoside-binding protein secreted by activated T cells inhibits antigen-induced proliferation of T cells" @default.
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• W1968372807 doi "https://doi.org/10.1002/(sici)1521-4141(199808)28:08<2311::aid-immu2311>3.0.co;2-g" @default.
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