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- W1968376432 abstract "Purpose of review Alcohol liver disease is second only to hepatitis C as the leading indication for liver transplantation in the United States. About 80% of alcohol liver disease cases present concurrent alcohol dependence, that is, histories of alcohol addiction. Recent findings We focus on disulfiram, naltrexone, and acamprosate, the only approved agents for the treatment of alcohol dependence. No outcome studies report use of any of the three agents in liver transplant patients. We therefore review recent studies of clinical effectiveness for each in treating alcohol dependence in nontransplant samples. Summary Disulfiram studies suggest strong clinical effects if ingestion is monitored, as in a clinic setting by professional staff, and transaminase levels are monitored carefully for reactions in the liver. Naltrexone appears to have no effect or a weak effect in alcohol-dependence treatment according to two large cooperative studies. This drug is also associated with rare toxic effects in the liver and requires transaminase monitoring. Acamprosate does not appear to be liver toxic but neither does it appear to be an effective treatment for alcohol dependence. Prospective drug treatment study of posttransplant patients with severe alcohol dependence may enlighten the use of such agents after liver grafting." @default.
- W1968376432 created "2016-06-24" @default.
- W1968376432 creator A5034216531 @default.
- W1968376432 creator A5063795924 @default.
- W1968376432 date "2007-04-01" @default.
- W1968376432 modified "2023-10-18" @default.
- W1968376432 title "The evidence for drug treatment of alcohol dependence in liver transplant patients" @default.
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- W1968376432 doi "https://doi.org/10.1097/mot.0b013e32803fb77d" @default.
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