FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968381010> ?p ?o ?g. }

• W1968381010 endingPage "16" @default.
• W1968381010 startingPage "10" @default.
• W1968381010 abstract "Liver ischemia/reperfusion (I/R) leads to formation of reactive oxygen species (ROS), which cause hepatic injury and initiate an inflammatory response, which is a critical problem after liver surgery and transplantation. Xanthohumol, the major prenylated chalcone found in hops, has been discussed for its anti-inflammatory and ROS-scavenging properties, and thus, we aimed to investigate the effect of xanthohumol in a model of warm I/R liver injury. Xanthohumol was applied to BALB/c mice orally at a dose of 1 mg/g body weight for 5 days before I/R-injury was induced by clamping the vascular blood supply to the median and left lateral liver lobe for 1 h followed by a 6 h period of reperfusion. At this time, HPLC analysis revealed hepatic xanthohumol levels of approximately 2 μM, a concentration which has been shown to inhibit inflammatory effects in vitro. Assessment of hepatic HMOX1 expression, hepatic glutathione content and immunohistochemical analysis for proteins conjugated with the reactive aldehyde 4-hydroxynonenal indicated that I/R-induced oxidative stress was significantly inhibited in xanthohumol-fed compared to control mice. Histological analysis, TUNEL staining and determination of transaminase serum levels revealed no significant effects of xanthohumol on acute hepatocellular injury. However, at the same time point, pretreatment with xanthohumol almost completely blunted the I/R-induced AKT and NFκB activation and the expression of the proinflammatory genes IL-1alpha, IL-6, MCP-1 and ICAM-1, which are known to play a crucial role in the subacute phase of I/R-induced liver damage. In conclusion, these data indicate the potential of xanthohumol application to prevent adverse inflammatory responses to I/R-induced liver damage such as after surgical liver resection or transplantation." @default.
• W1968381010 created "2016-06-24" @default.
• W1968381010 creator A5004896830 @default.
• W1968381010 creator A5031210648 @default.
• W1968381010 creator A5042439466 @default.
• W1968381010 creator A5060264183 @default.
• W1968381010 creator A5073049749 @default.
• W1968381010 date "2013-02-01" @default.
• W1968381010 modified "2023-10-06" @default.
• W1968381010 title "Xanthohumol suppresses inflammatory response to warm ischemia–reperfusion induced liver injury" @default.
• W1968381010 cites W1488683462 @default.
• W1968381010 cites W1506799643 @default.
• W1968381010 cites W1903318115 @default.
• W1968381010 cites W1965521369 @default.
• W1968381010 cites W1967527380 @default.
• W1968381010 cites W1970406868 @default.
• W1968381010 cites W1973749715 @default.
• W1968381010 cites W1974684736 @default.
• W1968381010 cites W1977557850 @default.
• W1968381010 cites W1978843109 @default.
• W1968381010 cites W1983803702 @default.
• W1968381010 cites W1992359311 @default.
• W1968381010 cites W1997093811 @default.
• W1968381010 cites W2014980326 @default.
• W1968381010 cites W2016223946 @default.
• W1968381010 cites W2021069569 @default.
• W1968381010 cites W2023252159 @default.
• W1968381010 cites W2036941062 @default.
• W1968381010 cites W2037005735 @default.
• W1968381010 cites W2039239252 @default.
• W1968381010 cites W2040464269 @default.
• W1968381010 cites W2048805706 @default.
• W1968381010 cites W2051078267 @default.
• W1968381010 cites W2055650512 @default.
• W1968381010 cites W2057069585 @default.
• W1968381010 cites W2063400200 @default.
• W1968381010 cites W2072096909 @default.
• W1968381010 cites W2074966179 @default.
• W1968381010 cites W2076769848 @default.
• W1968381010 cites W2080033686 @default.
• W1968381010 cites W2088019094 @default.
• W1968381010 cites W2092082915 @default.
• W1968381010 cites W2093008188 @default.
• W1968381010 cites W2099817964 @default.
• W1968381010 cites W2101696862 @default.
• W1968381010 cites W2105720872 @default.
• W1968381010 cites W2109855059 @default.
• W1968381010 cites W2111297725 @default.
• W1968381010 cites W2111761608 @default.
• W1968381010 cites W2118974930 @default.
• W1968381010 cites W2126917669 @default.
• W1968381010 cites W2130529820 @default.
• W1968381010 cites W2138608324 @default.
• W1968381010 cites W2140864155 @default.
• W1968381010 cites W2144628596 @default.
• W1968381010 cites W2156839094 @default.
• W1968381010 cites W2323098151 @default.
• W1968381010 cites W2999065750 @default.
• W1968381010 cites W4379365691 @default.
• W1968381010 doi "https://doi.org/10.1016/j.yexmp.2012.05.003" @default.
• W1968381010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22634733" @default.
• W1968381010 hasPublicationYear "2013" @default.
• W1968381010 type Work @default.
• W1968381010 sameAs 1968381010 @default.
• W1968381010 citedByCount "33" @default.
• W1968381010 countsByYear W19683810102012 @default.
• W1968381010 countsByYear W19683810102013 @default.
• W1968381010 countsByYear W19683810102015 @default.
• W1968381010 countsByYear W19683810102016 @default.
• W1968381010 countsByYear W19683810102017 @default.
• W1968381010 countsByYear W19683810102018 @default.
• W1968381010 countsByYear W19683810102019 @default.
• W1968381010 countsByYear W19683810102020 @default.
• W1968381010 countsByYear W19683810102021 @default.
• W1968381010 countsByYear W19683810102022 @default.
• W1968381010 countsByYear W19683810102023 @default.
• W1968381010 crossrefType "journal-article" @default.
• W1968381010 hasAuthorship W1968381010A5004896830 @default.
• W1968381010 hasAuthorship W1968381010A5031210648 @default.
• W1968381010 hasAuthorship W1968381010A5042439466 @default.
• W1968381010 hasAuthorship W1968381010A5060264183 @default.
• W1968381010 hasAuthorship W1968381010A5073049749 @default.
• W1968381010 hasConcept C126322002 @default.
• W1968381010 hasConcept C164027704 @default.
• W1968381010 hasConcept C181199279 @default.
• W1968381010 hasConcept C185592680 @default.
• W1968381010 hasConcept C18903297 @default.
• W1968381010 hasConcept C26517878 @default.
• W1968381010 hasConcept C2776151105 @default.
• W1968381010 hasConcept C2776637226 @default.
• W1968381010 hasConcept C2776914184 @default.
• W1968381010 hasConcept C2779642036 @default.
• W1968381010 hasConcept C2780114680 @default.
• W1968381010 hasConcept C48349386 @default.
• W1968381010 hasConcept C538909803 @default.
• W1968381010 hasConcept C541997718 @default.
• W1968381010 hasConcept C55493867 @default.
• W1968381010 hasConcept C71924100 @default.

• next