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• W1968384420 abstract "The gene transfer mediated by chitosan in CFBE41o − (a cystic‐fibrosis bronchial epithelial cell line) and HEK (a human embryonic kidney cell line) has been evaluated. Polyplexes based on chitosan and PEI (polyethyleneimine) using a luciferase and enhanced green fluorescent protein reporter plasmid showed that the transfection efficacy of polyplexes in the CFBE41o − cell line was poor compared with that in HEK cells. In the highly differentiated cystic‐fibrosis bronchial epithelial cell line the narrow‐size‐distributed chitosan shows enhanced transfection at a low pH compared with PEI. The enhanced transfection at lower pH could be a result of damage to the cell surface or changes in the cell‐surface charge, leading to better penetration of the cell membrane." @default.
• W1968384420 created "2016-06-24" @default.
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• W1968384420 date "2008-12-01" @default.
• W1968384420 modified "2023-10-18" @default.
• W1968384420 title "Chitosan as a carrier for non-viral gene transfer in a cystic-fibrosis cell line" @default.
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• W1968384420 doi "https://doi.org/10.1042/ba20070197" @default.
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