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- W1968389600 endingPage "232" @default.
- W1968389600 startingPage "213" @default.
- W1968389600 abstract "In its rare occurrence, Langerhans cell histiocytosis (LCH) is a dangerous but intriguing deviation of mononuclear phagocytes, especially dendritic cells (DCs). Clinically, the disease ranges from self-resolving or well manageable to severe and even fatal. LCH lesions in skin, bone, and other sites contain high numbers of cells with phenotypic features resembling LCs admixed with macrophages, T cells, eosinophils, and multinucleated giant cells. Here we review current progress in the LCH field based on two central questions: (i) are LCH cells intrinsically aberrant, and (ii) how does the lesion drive pathogenesis? We argue that LCH cells may originate from different sources, including epidermal LCs, tissue Langerin(+) DCs, or mononuclear phagocyte precursors. Current and prospective in vitro and in vivo models are discussed. Finally, we discuss recent insights into plasticity of T-helper cell subsets in light of the lesion microenvironment. LCH continues to provide urgent clinical questions thereby inspiring innovative DC lineage research." @default.
- W1968389600 created "2016-06-24" @default.
- W1968389600 creator A5003014435 @default.
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- W1968389600 creator A5007940009 @default.
- W1968389600 creator A5011264648 @default.
- W1968389600 creator A5012392552 @default.
- W1968389600 date "2010-03-01" @default.
- W1968389600 modified "2023-09-27" @default.
- W1968389600 title "Langerhans cell histiocytosis: fascinating dynamics of the dendritic cell-macrophage lineage" @default.
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