Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968391382> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W1968391382 abstract "The aim of this study was to evaluate the different bone resorption markers, total pyridinoline (Pyr) and total deoxypyridinoline (Dpyr), assessed by a HPLC method, free Dpyr, assessed by a new immunoassay, and urinary excretion of hydroxyproline (OH-proline), in postmenopausal osteoporotic women during long-term treatment with pamidronate. A total of 60 postmenopausal women with previous distal forearm fracture were included in this 12-month placebo-controlled and double-blind study, where intermittent oral pamidronate, 75 or 150 mg, or placebo were given daily for 4 weeks, every 16 weeks. After 1 week a significant reduction in urinary excretion of total Dpyr was observed in the group treated with 150 mg pamidronate compared to the placebo (p < 0.01) and to the 75-mg group (p < 0.001). A maximal 50.4% decrease in total Dpyr, (p < 0.0001 compared to the placebo group, p < 0.01 compared to the 75-mg group), was observed after 3 weeks of treatment with 150 mg pamidronate, and this decrease persisted to week 52. After 4 weeks of treatment with 150 mg pamidronate the maximal decrease in free Dpyr was only 26.5%, which persisted during 12 months of treatment. Decreases in urinary excretion of total Pyr and OH-proline were less than the decreases in total Dpyr. The correlation between total Dpyr (HPLC method) and free Dpyr (Pyrilinks-D assay) at baseline was r = 0.91. Total Dpyr assessed by the HPLC method reflects the pamidronate-induced decrease in bone resorption, and the changes in this resorption marker were more pronounced than changes in free Dpyr, total Pyr and OH-proline. In this study free Dpyr analysis was less suitable for reflecting bone resorption during bisphosphonate therapy." @default.
- W1968391382 created "2016-06-24" @default.
- W1968391382 creator A5025012427 @default.
- W1968391382 creator A5058207838 @default.
- W1968391382 creator A5064813866 @default.
- W1968391382 date "1997-01-01" @default.
- W1968391382 modified "2023-10-17" @default.
- W1968391382 title "Assessment of different markers of bone resorption in postmenopausal osteoporotic women treated with pamidronate" @default.
- W1968391382 cites W1965354004 @default.
- W1968391382 cites W1973168752 @default.
- W1968391382 cites W1975606701 @default.
- W1968391382 cites W1977603398 @default.
- W1968391382 cites W1996660957 @default.
- W1968391382 cites W2002104195 @default.
- W1968391382 cites W2022320063 @default.
- W1968391382 cites W2023726540 @default.
- W1968391382 cites W2056019384 @default.
- W1968391382 cites W2073025986 @default.
- W1968391382 cites W2085133234 @default.
- W1968391382 cites W2130289134 @default.
- W1968391382 cites W2154852947 @default.
- W1968391382 cites W2321127699 @default.
- W1968391382 doi "https://doi.org/10.3109/00365519709084597" @default.
- W1968391382 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9350066" @default.
- W1968391382 hasPublicationYear "1997" @default.
- W1968391382 type Work @default.
- W1968391382 sameAs 1968391382 @default.
- W1968391382 citedByCount "1" @default.
- W1968391382 crossrefType "journal-article" @default.
- W1968391382 hasAuthorship W1968391382A5025012427 @default.
- W1968391382 hasAuthorship W1968391382A5058207838 @default.
- W1968391382 hasAuthorship W1968391382A5064813866 @default.
- W1968391382 hasConcept C10146269 @default.
- W1968391382 hasConcept C126322002 @default.
- W1968391382 hasConcept C126894567 @default.
- W1968391382 hasConcept C131075544 @default.
- W1968391382 hasConcept C134018914 @default.
- W1968391382 hasConcept C142724271 @default.
- W1968391382 hasConcept C146562846 @default.
- W1968391382 hasConcept C160160445 @default.
- W1968391382 hasConcept C181199279 @default.
- W1968391382 hasConcept C185592680 @default.
- W1968391382 hasConcept C204787440 @default.
- W1968391382 hasConcept C27081682 @default.
- W1968391382 hasConcept C2776541429 @default.
- W1968391382 hasConcept C2778588143 @default.
- W1968391382 hasConcept C2779797417 @default.
- W1968391382 hasConcept C2780787237 @default.
- W1968391382 hasConcept C55493867 @default.
- W1968391382 hasConcept C673006 @default.
- W1968391382 hasConcept C71924100 @default.
- W1968391382 hasConceptScore W1968391382C10146269 @default.
- W1968391382 hasConceptScore W1968391382C126322002 @default.
- W1968391382 hasConceptScore W1968391382C126894567 @default.
- W1968391382 hasConceptScore W1968391382C131075544 @default.
- W1968391382 hasConceptScore W1968391382C134018914 @default.
- W1968391382 hasConceptScore W1968391382C142724271 @default.
- W1968391382 hasConceptScore W1968391382C146562846 @default.
- W1968391382 hasConceptScore W1968391382C160160445 @default.
- W1968391382 hasConceptScore W1968391382C181199279 @default.
- W1968391382 hasConceptScore W1968391382C185592680 @default.
- W1968391382 hasConceptScore W1968391382C204787440 @default.
- W1968391382 hasConceptScore W1968391382C27081682 @default.
- W1968391382 hasConceptScore W1968391382C2776541429 @default.
- W1968391382 hasConceptScore W1968391382C2778588143 @default.
- W1968391382 hasConceptScore W1968391382C2779797417 @default.
- W1968391382 hasConceptScore W1968391382C2780787237 @default.
- W1968391382 hasConceptScore W1968391382C55493867 @default.
- W1968391382 hasConceptScore W1968391382C673006 @default.
- W1968391382 hasConceptScore W1968391382C71924100 @default.
- W1968391382 hasLocation W19683913821 @default.
- W1968391382 hasLocation W19683913822 @default.
- W1968391382 hasOpenAccess W1968391382 @default.
- W1968391382 hasPrimaryLocation W19683913821 @default.
- W1968391382 hasRelatedWork W1994404770 @default.
- W1968391382 hasRelatedWork W2009834373 @default.
- W1968391382 hasRelatedWork W2021579123 @default.
- W1968391382 hasRelatedWork W2039435952 @default.
- W1968391382 hasRelatedWork W2051684105 @default.
- W1968391382 hasRelatedWork W2076169802 @default.
- W1968391382 hasRelatedWork W2122242665 @default.
- W1968391382 hasRelatedWork W2123410636 @default.
- W1968391382 hasRelatedWork W2153604269 @default.
- W1968391382 hasRelatedWork W2168490705 @default.
- W1968391382 isParatext "false" @default.
- W1968391382 isRetracted "false" @default.
- W1968391382 magId "1968391382" @default.
- W1968391382 workType "article" @default.