FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968394538> ?p ?o ?g. }

• W1968394538 endingPage "825" @default.
• W1968394538 startingPage "818" @default.
• W1968394538 abstract "The purpose of this study was to determine the relationship between matrix metalloproteinases (MMPs)-1, -2, and -9, and tissue inhibitors of metalloproteinases (TIMP)-1 and the atrial structural remodeling during atrial fibrillation (AF).Matrix metalloproteinases, a family of proteolytic enzymes and TIMPs, regulate the extracellular matrix turnover in cardiac tissue.Tissue samples were obtained from 25 patients without a history of AF (regular sinus rhythm [RSR]) and 13 patients with AF (paroxysmal AF: 6, chronic AF 7) undergoing cardiac operations. We performed a western blotting analysis of the MMP-1, -2, and -9, and quantitatively analyzed the expression of the MMP-9 and TIMP-1 by real time polymerase chain reaction and ELISA. The localization of the MMP-9 was investigated by in situ zymography and immunohistochemistry.The active form of the MMP-9 was significantly increased in the AF group in comparison to that in the RSR group (p < 0.05), but there were no differences between the groups in the protein level of the latent form of the MMP-9 and active and latent forms of the MMP-1 and MMP-2. We also demonstrated that the expression of the MMP-9 was significantly more increased in the atria of the AF group than in that of the RSR group for both the messenger ribonucleic acid (mRNA) (AF: RSR; 1: 1.5) and protein levels (AF: RSR; 3.9 +/- 1.3 : 1.5 +/- 0.4 ng/mg atrium). The expression level of the MMP-9 was also higher in the PAF group than in the RSR group, however, the diameter of the left atrium was similar in both groups. The gelatinase activity and left atrium diameter were positively correlated (p < 0.05, R = 0.766). The relative expression of the mRNA for the monocyte chemoattractant protein-1 was higher in the AF group than in the RSR group. Immunohistochemical analysis revealed that the MMP-9 was distributed within the perivascular area and under the epicardium of the atria.We clearly showed that the expression of the MMP-9 increased in fibrillating atrial tissue, which may have contributed to the atrial structural remodeling and atrial dilatation during AF." @default.
• W1968394538 created "2016-06-24" @default.
• W1968394538 creator A5018817193 @default.
• W1968394538 creator A5023958825 @default.
• W1968394538 creator A5033220097 @default.
• W1968394538 creator A5041829691 @default.
• W1968394538 creator A5042459281 @default.
• W1968394538 creator A5044197227 @default.
• W1968394538 creator A5063905870 @default.
• W1968394538 creator A5072801244 @default.
• W1968394538 creator A5077086654 @default.
• W1968394538 creator A5081712978 @default.
• W1968394538 creator A5082018968 @default.
• W1968394538 date "2004-03-01" @default.
• W1968394538 modified "2023-10-16" @default.
• W1968394538 title "Matrix metalloproteinase-9 contributes to human atrial remodeling during atrial fibrillation" @default.
• W1968394538 cites W1508529139 @default.
• W1968394538 cites W1971006006 @default.
• W1968394538 cites W1980930513 @default.
• W1968394538 cites W1982983732 @default.
• W1968394538 cites W1992912936 @default.
• W1968394538 cites W2009414043 @default.
• W1968394538 cites W2014377192 @default.
• W1968394538 cites W2017179259 @default.
• W1968394538 cites W2034282563 @default.
• W1968394538 cites W2038843437 @default.
• W1968394538 cites W2049993408 @default.
• W1968394538 cites W2060379181 @default.
• W1968394538 cites W2060486571 @default.
• W1968394538 cites W2082272659 @default.
• W1968394538 cites W2093032251 @default.
• W1968394538 cites W2093629370 @default.
• W1968394538 cites W2099601272 @default.
• W1968394538 cites W2102664563 @default.
• W1968394538 cites W2106319388 @default.
• W1968394538 cites W2107213822 @default.
• W1968394538 cites W2107714800 @default.
• W1968394538 cites W2124693576 @default.
• W1968394538 cites W2124894661 @default.
• W1968394538 cites W2125603290 @default.
• W1968394538 cites W2132290892 @default.
• W1968394538 cites W2133272765 @default.
• W1968394538 cites W2147005862 @default.
• W1968394538 cites W2150304491 @default.
• W1968394538 cites W2152003312 @default.
• W1968394538 cites W2152090961 @default.
• W1968394538 cites W2152669066 @default.
• W1968394538 cites W2155902512 @default.
• W1968394538 cites W2165967197 @default.
• W1968394538 cites W2169679878 @default.
• W1968394538 cites W2324628668 @default.
• W1968394538 cites W4255962172 @default.
• W1968394538 doi "https://doi.org/10.1016/j.jacc.2003.08.060" @default.
• W1968394538 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14998623" @default.
• W1968394538 hasPublicationYear "2004" @default.
• W1968394538 type Work @default.
• W1968394538 sameAs 1968394538 @default.
• W1968394538 citedByCount "134" @default.
• W1968394538 countsByYear W19683945382012 @default.
• W1968394538 countsByYear W19683945382013 @default.
• W1968394538 countsByYear W19683945382014 @default.
• W1968394538 countsByYear W19683945382015 @default.
• W1968394538 countsByYear W19683945382016 @default.
• W1968394538 countsByYear W19683945382017 @default.
• W1968394538 countsByYear W19683945382018 @default.
• W1968394538 countsByYear W19683945382019 @default.
• W1968394538 countsByYear W19683945382020 @default.
• W1968394538 countsByYear W19683945382021 @default.
• W1968394538 countsByYear W19683945382022 @default.
• W1968394538 countsByYear W19683945382023 @default.
• W1968394538 crossrefType "journal-article" @default.
• W1968394538 hasAuthorship W1968394538A5018817193 @default.
• W1968394538 hasAuthorship W1968394538A5023958825 @default.
• W1968394538 hasAuthorship W1968394538A5033220097 @default.
• W1968394538 hasAuthorship W1968394538A5041829691 @default.
• W1968394538 hasAuthorship W1968394538A5042459281 @default.
• W1968394538 hasAuthorship W1968394538A5044197227 @default.
• W1968394538 hasAuthorship W1968394538A5063905870 @default.
• W1968394538 hasAuthorship W1968394538A5072801244 @default.
• W1968394538 hasAuthorship W1968394538A5077086654 @default.
• W1968394538 hasAuthorship W1968394538A5081712978 @default.
• W1968394538 hasAuthorship W1968394538A5082018968 @default.
• W1968394538 hasBestOaLocation W19683945381 @default.
• W1968394538 hasConcept C104317684 @default.
• W1968394538 hasConcept C105580179 @default.
• W1968394538 hasConcept C109523444 @default.
• W1968394538 hasConcept C114021368 @default.
• W1968394538 hasConcept C126322002 @default.
• W1968394538 hasConcept C134018914 @default.
• W1968394538 hasConcept C164705383 @default.
• W1968394538 hasConcept C177430391 @default.
• W1968394538 hasConcept C185592680 @default.
• W1968394538 hasConcept C189165786 @default.
• W1968394538 hasConcept C204232928 @default.
• W1968394538 hasConcept C2775914520 @default.
• W1968394538 hasConcept C2779161974 @default.
• W1968394538 hasConcept C55493867 @default.
• W1968394538 hasConcept C71924100 @default.

• next