FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968401611> ?p ?o ?g. }

• W1968401611 endingPage "39" @default.
• W1968401611 startingPage "25" @default.
• W1968401611 abstract "Parallel fiber growth was studied during the postnatal period and adulthood in controls and rats made hypo- or hyperthyroid from birth, using a lesioning and degeneration staining method for the direct determination of parallel fiber length. In control animals, parallel fiber growth was rapid from 10 to 30 days of age, followed by a period of much slower growth into adulthood, when parallel fibers reached a maximum length of approximately 5 mm. Hypothyroidism retarded parallel fiber development, especially at 15 and 30 days, resulting in permanently shorter parallel fibers in at least one lobule (IV). Hyperthyroidism accelerated and prolonged growth of parallel fibers, producing adult fibers as much as 1.5 mm longer than controls (lobule V). The possible functional significance of this effect is discussed. The consequences of neonatal hypo- and hyperthyroidism for the synaptic capacity of adult parallel fibers was also examined using the rapid Golgi method. Parallel fibers of hypothyroid animals were dificient in the density of varicosities (sites of synapses with Purkinje cells) along their surface. In combination with the reduced length of these axons, this resulted in a deficit in the total number of synaptic sites per parallel fiber, a result consistent with our previous finding of a general synaptic hypoplasia in the hypothyroid molecular layer. Hyperthyroidism, while stimulating increased parallel fiber growth, did not change the density of varicosities along the parallel fibers. The increased length of these axons, however, did produce an increase in the total number of synaptic sites per parallel fiber. This finding substantiates our previous prediction that, due to the pronounced deficit in granule cells, each parallel fiber must make more than the normal number of synapses in order to achieve the normal synaptic density observed in the adult hyperthyroid molecular layer. This raises the possibility that hyperthyroidism may change the rate of synaptogenesis mainly as a consequence of the stimulation of axonal (and dendritic) growth rather than by affecting synaptogenic events directly. Implications for hormonal control of rates of axonal growth and synaptogenesis in the developing cerebellum are considered, as well as possible mechanisms responsible for these effects." @default.
• W1968401611 created "2016-06-24" @default.
• W1968401611 creator A5077906241 @default.
• W1968401611 date "1978-02-01" @default.
• W1968401611 modified "2023-09-25" @default.
• W1968401611 title "Effects of early hypo- and hyperthyroidism on development of rat cerebellar cortex. IV. The parallel fibers" @default.
• W1968401611 cites W121623384 @default.
• W1968401611 cites W1497004239 @default.
• W1968401611 cites W1576414414 @default.
• W1968401611 cites W1971407845 @default.
• W1968401611 cites W1974314302 @default.
• W1968401611 cites W1975558427 @default.
• W1968401611 cites W1976634805 @default.
• W1968401611 cites W1984233846 @default.
• W1968401611 cites W1985177442 @default.
• W1968401611 cites W1990935177 @default.
• W1968401611 cites W1999979999 @default.
• W1968401611 cites W2000243326 @default.
• W1968401611 cites W2001896618 @default.
• W1968401611 cites W2008546749 @default.
• W1968401611 cites W2011101649 @default.
• W1968401611 cites W2015056774 @default.
• W1968401611 cites W2015499111 @default.
• W1968401611 cites W2019643721 @default.
• W1968401611 cites W2019720629 @default.
• W1968401611 cites W2024088267 @default.
• W1968401611 cites W2024454572 @default.
• W1968401611 cites W2024812920 @default.
• W1968401611 cites W2033298972 @default.
• W1968401611 cites W2040448270 @default.
• W1968401611 cites W2040550039 @default.
• W1968401611 cites W2043433412 @default.
• W1968401611 cites W2045559518 @default.
• W1968401611 cites W2048073440 @default.
• W1968401611 cites W2053411770 @default.
• W1968401611 cites W2056813204 @default.
• W1968401611 cites W2059038971 @default.
• W1968401611 cites W2059345942 @default.
• W1968401611 cites W2063040594 @default.
• W1968401611 cites W2071915811 @default.
• W1968401611 cites W2072559056 @default.
• W1968401611 cites W2077532540 @default.
• W1968401611 cites W2087409229 @default.
• W1968401611 cites W2092713296 @default.
• W1968401611 cites W2094306155 @default.
• W1968401611 cites W2105578257 @default.
• W1968401611 cites W2114611737 @default.
• W1968401611 cites W2123947162 @default.
• W1968401611 cites W2129285197 @default.
• W1968401611 cites W2135604866 @default.
• W1968401611 cites W2142022378 @default.
• W1968401611 cites W2161752531 @default.
• W1968401611 cites W2395543269 @default.
• W1968401611 cites W2409499000 @default.
• W1968401611 cites W2418765011 @default.
• W1968401611 cites W3015287716 @default.
• W1968401611 cites W334258474 @default.
• W1968401611 doi "https://doi.org/10.1016/0006-8993(78)90174-9" @default.
• W1968401611 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/626917" @default.
• W1968401611 hasPublicationYear "1978" @default.
• W1968401611 type Work @default.
• W1968401611 sameAs 1968401611 @default.
• W1968401611 citedByCount "81" @default.
• W1968401611 countsByYear W19684016112012 @default.
• W1968401611 countsByYear W19684016112014 @default.
• W1968401611 countsByYear W19684016112015 @default.
• W1968401611 countsByYear W19684016112016 @default.
• W1968401611 countsByYear W19684016112017 @default.
• W1968401611 countsByYear W19684016112019 @default.
• W1968401611 countsByYear W19684016112021 @default.
• W1968401611 countsByYear W19684016112022 @default.
• W1968401611 countsByYear W19684016112023 @default.
• W1968401611 crossrefType "journal-article" @default.
• W1968401611 hasAuthorship W1968401611A5077906241 @default.
• W1968401611 hasConcept C105702510 @default.
• W1968401611 hasConcept C126322002 @default.
• W1968401611 hasConcept C134018914 @default.
• W1968401611 hasConcept C169760540 @default.
• W1968401611 hasConcept C178790620 @default.
• W1968401611 hasConcept C185592680 @default.
• W1968401611 hasConcept C2778058767 @default.
• W1968401611 hasConcept C2779652256 @default.
• W1968401611 hasConcept C2992333117 @default.
• W1968401611 hasConcept C519885992 @default.
• W1968401611 hasConcept C71924100 @default.
• W1968401611 hasConcept C86803240 @default.
• W1968401611 hasConceptScore W1968401611C105702510 @default.
• W1968401611 hasConceptScore W1968401611C126322002 @default.
• W1968401611 hasConceptScore W1968401611C134018914 @default.
• W1968401611 hasConceptScore W1968401611C169760540 @default.
• W1968401611 hasConceptScore W1968401611C178790620 @default.
• W1968401611 hasConceptScore W1968401611C185592680 @default.
• W1968401611 hasConceptScore W1968401611C2778058767 @default.
• W1968401611 hasConceptScore W1968401611C2779652256 @default.
• W1968401611 hasConceptScore W1968401611C2992333117 @default.
• W1968401611 hasConceptScore W1968401611C519885992 @default.
• W1968401611 hasConceptScore W1968401611C71924100 @default.
• W1968401611 hasConceptScore W1968401611C86803240 @default.

• next