FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968409126> ?p ?o ?g. }

• W1968409126 endingPage "430" @default.
• W1968409126 startingPage "426" @default.
• W1968409126 abstract "Endothelial nitric oxide synthase (eNOS) produces nitric oxide (NO) which, after diffusing into vascular smooth muscle cells, activates guanylate cyclase leading to vasodilatation. A polymorphism (894G to T) in exon 7 of the eNOS gene causes the conversion of Glu to Asp in position 298. The recently described crystal structure of the heme domain of eNOS protein shows that Glu298 is fully solvent accessible and distant from regions integral to enzyme function. Searching for phenotypic expression of eNOS gene variants, we genotyped a group of patients with essential hypertension (H, n = 119) for the Glu298Asp polymorphism and compared them with age- and sex-matched healthy normals (N, n = 85). To specify phenotypic expression further, the hypertensive patients were subdivided into one group that responded well to regular antihypertensive therapy (CH, n = 45) and one group that was resistant to the therapy (RH, n = 74). Patients with BP higher than 140/90 mmHg when on adequate lifestyle modification and triple-combination therapy (including diuretics) were considered resistant. In RH and H groups, a significantly higher frequency of T alleles (P = 0.022 and P = 0.046, respectively) was found compared to normotonics (N). In well-controlled hypertonics, the same tendency was found, but did not reach statistical significance. The Glu298Asp polymorphism may contribute to the complex pathogenesis of essential hypertension and may be a factor in the resistance of these patients to conventional antihypertensive therapy. The presence of this allele may thus be predictive of the patients' therapeutic response." @default.
• W1968409126 created "2016-06-24" @default.
• W1968409126 creator A5026413952 @default.
• W1968409126 creator A5039105876 @default.
• W1968409126 creator A5040086091 @default.
• W1968409126 creator A5055583533 @default.
• W1968409126 creator A5067253674 @default.
• W1968409126 creator A5071980210 @default.
• W1968409126 creator A5083780930 @default.
• W1968409126 date "2001-06-01" @default.
• W1968409126 modified "2023-10-15" @default.
• W1968409126 title "Association of the Glu298Asp Polymorphism in the Endothelial Nitric Oxide Synthase Gene with Essential Hypertension Resistant to Conventional Therapy" @default.
• W1968409126 cites W1479676079 @default.
• W1968409126 cites W1519102962 @default.
• W1968409126 cites W1800678382 @default.
• W1968409126 cites W1908877967 @default.
• W1968409126 cites W1963827194 @default.
• W1968409126 cites W1972561326 @default.
• W1968409126 cites W1987149804 @default.
• W1968409126 cites W1992040345 @default.
• W1968409126 cites W1993225843 @default.
• W1968409126 cites W1996465975 @default.
• W1968409126 cites W2001625922 @default.
• W1968409126 cites W2004398529 @default.
• W1968409126 cites W2006705030 @default.
• W1968409126 cites W2009013636 @default.
• W1968409126 cites W2011846765 @default.
• W1968409126 cites W2016054237 @default.
• W1968409126 cites W2026425756 @default.
• W1968409126 cites W2036700374 @default.
• W1968409126 cites W2040901946 @default.
• W1968409126 cites W2044941841 @default.
• W1968409126 cites W2069083293 @default.
• W1968409126 cites W2071186420 @default.
• W1968409126 cites W2075509284 @default.
• W1968409126 cites W2076795933 @default.
• W1968409126 cites W2119093576 @default.
• W1968409126 cites W2137237735 @default.
• W1968409126 cites W2140068354 @default.
• W1968409126 cites W2141537184 @default.
• W1968409126 cites W2141719916 @default.
• W1968409126 cites W2147534219 @default.
• W1968409126 cites W2150616706 @default.
• W1968409126 cites W2311246384 @default.
• W1968409126 cites W2341272418 @default.
• W1968409126 cites W4252349219 @default.
• W1968409126 cites W4365787936 @default.
• W1968409126 cites W4385996143 @default.
• W1968409126 doi "https://doi.org/10.1006/bbrc.2001.5007" @default.
• W1968409126 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11394896" @default.
• W1968409126 hasPublicationYear "2001" @default.
• W1968409126 type Work @default.
• W1968409126 sameAs 1968409126 @default.
• W1968409126 citedByCount "97" @default.
• W1968409126 countsByYear W19684091262012 @default.
• W1968409126 countsByYear W19684091262013 @default.
• W1968409126 countsByYear W19684091262014 @default.
• W1968409126 countsByYear W19684091262015 @default.
• W1968409126 countsByYear W19684091262016 @default.
• W1968409126 countsByYear W19684091262017 @default.
• W1968409126 countsByYear W19684091262018 @default.
• W1968409126 countsByYear W19684091262020 @default.
• W1968409126 countsByYear W19684091262021 @default.
• W1968409126 countsByYear W19684091262022 @default.
• W1968409126 countsByYear W19684091262023 @default.
• W1968409126 crossrefType "journal-article" @default.
• W1968409126 hasAuthorship W1968409126A5026413952 @default.
• W1968409126 hasAuthorship W1968409126A5039105876 @default.
• W1968409126 hasAuthorship W1968409126A5040086091 @default.
• W1968409126 hasAuthorship W1968409126A5055583533 @default.
• W1968409126 hasAuthorship W1968409126A5067253674 @default.
• W1968409126 hasAuthorship W1968409126A5071980210 @default.
• W1968409126 hasAuthorship W1968409126A5083780930 @default.
• W1968409126 hasConcept C104317684 @default.
• W1968409126 hasConcept C120770815 @default.
• W1968409126 hasConcept C126322002 @default.
• W1968409126 hasConcept C134018914 @default.
• W1968409126 hasConcept C149737253 @default.
• W1968409126 hasConcept C180754005 @default.
• W1968409126 hasConcept C2777097880 @default.
• W1968409126 hasConcept C2777622882 @default.
• W1968409126 hasConcept C2778326061 @default.
• W1968409126 hasConcept C2780942790 @default.
• W1968409126 hasConcept C519581460 @default.
• W1968409126 hasConcept C54355233 @default.
• W1968409126 hasConcept C71924100 @default.
• W1968409126 hasConcept C76252995 @default.
• W1968409126 hasConcept C84393581 @default.
• W1968409126 hasConcept C86803240 @default.
• W1968409126 hasConceptScore W1968409126C104317684 @default.
• W1968409126 hasConceptScore W1968409126C120770815 @default.
• W1968409126 hasConceptScore W1968409126C126322002 @default.
• W1968409126 hasConceptScore W1968409126C134018914 @default.
• W1968409126 hasConceptScore W1968409126C149737253 @default.
• W1968409126 hasConceptScore W1968409126C180754005 @default.
• W1968409126 hasConceptScore W1968409126C2777097880 @default.
• W1968409126 hasConceptScore W1968409126C2777622882 @default.
• W1968409126 hasConceptScore W1968409126C2778326061 @default.

• next