Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968428992> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W1968428992 endingPage "595" @default.
- W1968428992 startingPage "591" @default.
- W1968428992 abstract "To elucidate the role of cAMP in the secretion of ACTH, the effect of (1) three phosphodiesterase inhibitors, (2) forskolin, and (3) 8Bromo-cAMP, on CRF mediated ACTH release was studied in rat pituitary cell culture. The action of glucocorticoids on CRF induced cAMP accumulation and ACTH release was investigated. Isobutyl-methylxanthine (IBMX), caffeine, and forskolin augmented the release of ACTH induced from CRF 1.0 nM by 17%, 39%, and 20%, respectively. Also IBMX and caffeine potentiated CRF 10 nM stimulated ACTH release by 32% and 20%. Doses of forskolin and 8Bromo-cAMP, which alone stimulate large amounts of ACTH release, did not increase the amount of ACTH released from CRF 100 nM stimulated cells. Cortisol (500 nM) and corticosterone (500 nM) inhibited CRF induced intracellular cAMP by 39% and 26% while inhibiting pituitary ACTH release by 40% and 52%. In conclusion, cAMP plays an important role in the mechanism of ACTH secretion and it appears the final intracellular mechanism of CRF stimulated ACTH is via cAMP. Also, glucocorticoids exert their inhibitory influence prior to cAMP generation." @default.
- W1968428992 created "2016-06-24" @default.
- W1968428992 creator A5053424009 @default.
- W1968428992 date "1985-07-01" @default.
- W1968428992 modified "2023-10-05" @default.
- W1968428992 title "Role of cyclic AMP in corticotropin releasing factor mediated ACTH release" @default.
- W1968428992 cites W1493629431 @default.
- W1968428992 cites W1524880303 @default.
- W1968428992 cites W1969152654 @default.
- W1968428992 cites W1982959552 @default.
- W1968428992 cites W1984520419 @default.
- W1968428992 cites W1990931289 @default.
- W1968428992 cites W1994590235 @default.
- W1968428992 cites W1995421134 @default.
- W1968428992 cites W2010815233 @default.
- W1968428992 cites W2017312144 @default.
- W1968428992 cites W2026017784 @default.
- W1968428992 cites W2041166656 @default.
- W1968428992 cites W2047502333 @default.
- W1968428992 cites W2066748182 @default.
- W1968428992 cites W2095036452 @default.
- W1968428992 cites W2442295771 @default.
- W1968428992 cites W4376848280 @default.
- W1968428992 doi "https://doi.org/10.1016/0196-9781(85)90158-5" @default.
- W1968428992 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2415953" @default.
- W1968428992 hasPublicationYear "1985" @default.
- W1968428992 type Work @default.
- W1968428992 sameAs 1968428992 @default.
- W1968428992 citedByCount "14" @default.
- W1968428992 countsByYear W19684289922021 @default.
- W1968428992 crossrefType "journal-article" @default.
- W1968428992 hasAuthorship W1968428992A5053424009 @default.
- W1968428992 hasConcept C126322002 @default.
- W1968428992 hasConcept C134018914 @default.
- W1968428992 hasConcept C181199279 @default.
- W1968428992 hasConcept C185592680 @default.
- W1968428992 hasConcept C24998067 @default.
- W1968428992 hasConcept C2776766087 @default.
- W1968428992 hasConcept C2778500429 @default.
- W1968428992 hasConcept C2779276759 @default.
- W1968428992 hasConcept C2780352252 @default.
- W1968428992 hasConcept C2780546910 @default.
- W1968428992 hasConcept C2781298581 @default.
- W1968428992 hasConcept C2909643783 @default.
- W1968428992 hasConcept C49039625 @default.
- W1968428992 hasConcept C55493867 @default.
- W1968428992 hasConcept C62826618 @default.
- W1968428992 hasConcept C71315377 @default.
- W1968428992 hasConcept C71924100 @default.
- W1968428992 hasConcept C79879829 @default.
- W1968428992 hasConcept C86803240 @default.
- W1968428992 hasConceptScore W1968428992C126322002 @default.
- W1968428992 hasConceptScore W1968428992C134018914 @default.
- W1968428992 hasConceptScore W1968428992C181199279 @default.
- W1968428992 hasConceptScore W1968428992C185592680 @default.
- W1968428992 hasConceptScore W1968428992C24998067 @default.
- W1968428992 hasConceptScore W1968428992C2776766087 @default.
- W1968428992 hasConceptScore W1968428992C2778500429 @default.
- W1968428992 hasConceptScore W1968428992C2779276759 @default.
- W1968428992 hasConceptScore W1968428992C2780352252 @default.
- W1968428992 hasConceptScore W1968428992C2780546910 @default.
- W1968428992 hasConceptScore W1968428992C2781298581 @default.
- W1968428992 hasConceptScore W1968428992C2909643783 @default.
- W1968428992 hasConceptScore W1968428992C49039625 @default.
- W1968428992 hasConceptScore W1968428992C55493867 @default.
- W1968428992 hasConceptScore W1968428992C62826618 @default.
- W1968428992 hasConceptScore W1968428992C71315377 @default.
- W1968428992 hasConceptScore W1968428992C71924100 @default.
- W1968428992 hasConceptScore W1968428992C79879829 @default.
- W1968428992 hasConceptScore W1968428992C86803240 @default.
- W1968428992 hasIssue "4" @default.
- W1968428992 hasLocation W19684289921 @default.
- W1968428992 hasLocation W19684289922 @default.
- W1968428992 hasOpenAccess W1968428992 @default.
- W1968428992 hasPrimaryLocation W19684289921 @default.
- W1968428992 hasRelatedWork W1925741490 @default.
- W1968428992 hasRelatedWork W1953917057 @default.
- W1968428992 hasRelatedWork W1968428992 @default.
- W1968428992 hasRelatedWork W1995265880 @default.
- W1968428992 hasRelatedWork W2058024551 @default.
- W1968428992 hasRelatedWork W2089664452 @default.
- W1968428992 hasRelatedWork W2095774675 @default.
- W1968428992 hasRelatedWork W2106106547 @default.
- W1968428992 hasRelatedWork W2420945715 @default.
- W1968428992 hasRelatedWork W46890177 @default.
- W1968428992 hasVolume "6" @default.
- W1968428992 isParatext "false" @default.
- W1968428992 isRetracted "false" @default.
- W1968428992 magId "1968428992" @default.
- W1968428992 workType "article" @default.