FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968432883> ?p ?o ?g. }

• W1968432883 endingPage "77" @default.
• W1968432883 startingPage "65" @default.
• W1968432883 abstract "Recent studies have reported decreased overall severe sepsis mortality, but associations with organism trends have not yet been investigated. This study explored organism-specific severe sepsis mortality trends from 1999 to 2008 in a large hospital-based administrative database.Secondary data analysis using the Nationwide Inpatient Sample.United States hospitals sampled in the Nationwide Inpatient Sample dataset.This sample approximates a stratified 20% sample of all nonfederal, short-term, general, and specialty hospitals serving adults in the United States. Severe sepsis hospitalizations and organism-specific causes were identified using predetermined International Classification of Diseases, 9th Revision, Clinical Modification codes.None.Analysis was conducted using descriptive Cox proportional hazards and linear regression trend analysis. Adjustments were made for the influence of demographics, comorbidities, number of organisms, and number of organ failures on hospital mortality. The data for 5,033,257 severe sepsis hospitalizations were examined and revealed decreased in-hospital mortality from 40.0% to 27.8% during the study period. The leading cause of severe sepsis was 51.5% Gram-negative bacteria, followed by 45.6% Gram-positive, 1.7% anaerobic, and 1.2% fungal species. The most common Gram-negative organisms were 39.9% Escherichia coli and 17.6% Pseudomonas. Staphylococcus species (62.2% methicillin-sensitive Staphylococcus aureus and 22.6% Streptococcus) were the most commonly reported Gram-positive organisms. Crude mortality estimates were higher for anaerobic and fungal organisms, 34.5% and 31.4%, respectively. Among Gram-positive bacteria, mortality was highest for methicillin-sensitive S. aureus, 30.9%, whereas Pseudomonas was associated with the highest mortality for Gram-negative septicemia cases, 29.5%. After adjusting for covariates, anaerobes were associated with the highest mortality hazard of 1.31 (95% CI, 1.23-1.40). Methicillin-resistant S. aureus had the highest mortality hazard of 1.38 (1.33-1.44) for Gram-positive organisms, whereas all Gram-negative bacteria had decreased mortality hazards.We not only confirmed an overall decline in severe sepsis mortality from 1999 to 2008 but also identified previously unreported variations in organism-specific severe sepsis mortality. Gram-negative organisms predominate, whereas anaerobes and methicillin-resistant S. aureus are significant predictors of mortality. Future clinical trials exploring new treatments in severe sepsis should incorporate individual organism trends to elucidate potential effect on mortality." @default.
• W1968432883 created "2016-06-24" @default.
• W1968432883 creator A5006241042 @default.
• W1968432883 creator A5028504074 @default.
• W1968432883 creator A5045941257 @default.
• W1968432883 creator A5049536070 @default.
• W1968432883 date "2015-01-01" @default.
• W1968432883 modified "2023-09-30" @default.
• W1968432883 title "Variations in Organism-Specific Severe Sepsis Mortality in the United States" @default.
• W1968432883 cites W1713440487 @default.
• W1968432883 cites W1770614721 @default.
• W1968432883 cites W1789064953 @default.
• W1968432883 cites W1967278969 @default.
• W1968432883 cites W1968201338 @default.
• W1968432883 cites W1978800665 @default.
• W1968432883 cites W1979174301 @default.
• W1968432883 cites W1986612880 @default.
• W1968432883 cites W1993397663 @default.
• W1968432883 cites W1999164035 @default.
• W1968432883 cites W2006558163 @default.
• W1968432883 cites W2019349925 @default.
• W1968432883 cites W2019952254 @default.
• W1968432883 cites W2023521161 @default.
• W1968432883 cites W2029512625 @default.
• W1968432883 cites W2044750677 @default.
• W1968432883 cites W2054938569 @default.
• W1968432883 cites W2060122053 @default.
• W1968432883 cites W2068773073 @default.
• W1968432883 cites W2080678931 @default.
• W1968432883 cites W2091562993 @default.
• W1968432883 cites W2091989722 @default.
• W1968432883 cites W2098022350 @default.
• W1968432883 cites W2104010066 @default.
• W1968432883 cites W2104825124 @default.
• W1968432883 cites W2111682663 @default.
• W1968432883 cites W2113216559 @default.
• W1968432883 cites W2114449734 @default.
• W1968432883 cites W2117196810 @default.
• W1968432883 cites W2122267759 @default.
• W1968432883 cites W2125130883 @default.
• W1968432883 cites W2125733555 @default.
• W1968432883 cites W2126812384 @default.
• W1968432883 cites W2145577370 @default.
• W1968432883 cites W2148422817 @default.
• W1968432883 cites W2148440281 @default.
• W1968432883 cites W2157744708 @default.
• W1968432883 cites W2163392158 @default.
• W1968432883 cites W2164990391 @default.
• W1968432883 cites W2165158988 @default.
• W1968432883 cites W2170285826 @default.
• W1968432883 cites W2325491525 @default.
• W1968432883 cites W2397664387 @default.
• W1968432883 cites W3023757607 @default.
• W1968432883 cites W4237193230 @default.
• W1968432883 cites W4243836839 @default.
• W1968432883 cites W4245690870 @default.
• W1968432883 doi "https://doi.org/10.1097/ccm.0000000000000555" @default.
• W1968432883 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25230374" @default.
• W1968432883 hasPublicationYear "2015" @default.
• W1968432883 type Work @default.
• W1968432883 sameAs 1968432883 @default.
• W1968432883 citedByCount "66" @default.
• W1968432883 countsByYear W19684328832014 @default.
• W1968432883 countsByYear W19684328832015 @default.
• W1968432883 countsByYear W19684328832016 @default.
• W1968432883 countsByYear W19684328832017 @default.
• W1968432883 countsByYear W19684328832018 @default.
• W1968432883 countsByYear W19684328832019 @default.
• W1968432883 countsByYear W19684328832020 @default.
• W1968432883 countsByYear W19684328832021 @default.
• W1968432883 countsByYear W19684328832022 @default.
• W1968432883 countsByYear W19684328832023 @default.
• W1968432883 crossrefType "journal-article" @default.
• W1968432883 hasAuthorship W1968432883A5006241042 @default.
• W1968432883 hasAuthorship W1968432883A5028504074 @default.
• W1968432883 hasAuthorship W1968432883A5045941257 @default.
• W1968432883 hasAuthorship W1968432883A5049536070 @default.
• W1968432883 hasConcept C126322002 @default.
• W1968432883 hasConcept C177713679 @default.
• W1968432883 hasConcept C179755657 @default.
• W1968432883 hasConcept C2778384902 @default.
• W1968432883 hasConcept C2779489039 @default.
• W1968432883 hasConcept C42407357 @default.
• W1968432883 hasConcept C50382708 @default.
• W1968432883 hasConcept C5140985 @default.
• W1968432883 hasConcept C523546767 @default.
• W1968432883 hasConcept C54355233 @default.
• W1968432883 hasConcept C71924100 @default.
• W1968432883 hasConcept C86803240 @default.
• W1968432883 hasConceptScore W1968432883C126322002 @default.
• W1968432883 hasConceptScore W1968432883C177713679 @default.
• W1968432883 hasConceptScore W1968432883C179755657 @default.
• W1968432883 hasConceptScore W1968432883C2778384902 @default.
• W1968432883 hasConceptScore W1968432883C2779489039 @default.
• W1968432883 hasConceptScore W1968432883C42407357 @default.
• W1968432883 hasConceptScore W1968432883C50382708 @default.
• W1968432883 hasConceptScore W1968432883C5140985 @default.
• W1968432883 hasConceptScore W1968432883C523546767 @default.

• next