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- W1968442011 abstract "While classical neuroleptics are characterized by dopamine D(2) antagonism, this is also considered to be the cause of their neurological side effects. In recent years, novel antipsychotic drugs with improved efficacy, devoid of extrapyramidal effects are being developed. The mechanisms of action of these new atypical antipsychotics can be classified into three general groups: a) binding to D(2) together with non-dopaminergic receptors, b) interaction with dopamine receptor subtypes other than D(2) and c) selective binding to non-dopaminergic systems, such as glutamatergic, sigma, neurotensin, and cannabinoid." @default.
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- W1968442011 date "2003-05-01" @default.
- W1968442011 modified "2023-10-16" @default.
- W1968442011 title "Current Strategies for the Development of Novel Antipsychotic Drugs" @default.
- W1968442011 doi "https://doi.org/10.2174/1389557033488169" @default.
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