FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968442373> ?p ?o ?g. }

• W1968442373 endingPage "864" @default.
• W1968442373 startingPage "858" @default.
• W1968442373 abstract "Transdermal systems for delivery of nitroglycerin have been shown to provide sustained blood levels of the drug for at least 24 hours. Investigations of hemodynamic effects of transdermal nitroglycerin in patients with heart failure have demonstrated a transient reduction in pressure lasting less than the expected 24 hours. These findings could be due to the development of circulatory tolerance to the vasodilatory effects of nitroglycerin or to insufficient drug dosing. In the present study, we compared the hemodynamic effects of the first and the second doses of high dose (120 mg) transdermal nitroglycerin given 24 hours apart in 11 responders (≥20% reduction in mean pulmonary artery wedge pressure lasting ≥2 hours). Initiation of nitroglycerin therapy resulted in a significant reduction in mean right atrial pressure lasting for 14 hours and in a reduction in mean pulmonary artery and mean pulmonary artery wedge pressures lasting 24 hours. After administration of the second dose, mean right atrial pressure at 2 hours (9 ± 5 versus 7 ± 4 mm Hg), 4 hours (8 ± 5 versus 6 ± 4 mm Hg) and 8 hours (8 ± 5 versus 6 ± 3 mm Hg) was higher than after the first dose (p < 0.05). Both mean pulmonary artery and mean pulmonary artery wedge pressures were significantly higher after the second nitroglycerin dose. Mean pulmonary artery pressure after the second dose was 32 ± 8 versus 28 ± 7 mm Hg at 2 hours (p < 0.05), 32 ± 7 versus 27 ± 7 mm Hg at 4 hours (p < 0.01), 33 ± 10 versus 27 ± 6 mm Hg at 6 hours (p < 0.05) and 31 ± 8 versus 26 ± 7 mm Hg at 8 hours (p < 0.05). Mean pulmonary artery wedge pressure was 22 ± 7 versus 17 ± 7 mm Hg at 2 hours (p < 0.01), 21 ± 8 versus 16 ± 6 mm Hg at 4 hours (p < 0.01), 19 ± 8 versus 16 ± 7 mm Hg at 6 hours (p < 0.05) and 20 ± 9 versus 15 ± 6 mm Hg at 8 hours (p < 0.01). It is concluded that in patients with chronic congestive heart failure, the initial hemodynamic changes seen after the administration of high dose transdermal nitroglycerin are significantly attenuated within hours of the first dose. These findings suggest that circulatory tolerance to the effect of sustained nitroglycerin therapy develops early and should be taken into consideration when transdermal nitroglycerin is used in short- and long-term therapy of chronic heart failure." @default.
• W1968442373 created "2016-06-24" @default.
• W1968442373 creator A5039521418 @default.
• W1968442373 creator A5039838157 @default.
• W1968442373 creator A5041120210 @default.
• W1968442373 creator A5041791481 @default.
• W1968442373 creator A5082162481 @default.
• W1968442373 creator A5087673809 @default.
• W1968442373 date "1987-04-01" @default.
• W1968442373 modified "2023-09-27" @default.
• W1968442373 title "Early tolerance to hemodynamic effects of high dose transdermal nitroglycerin in responders with severe chronic heart failure" @default.
• W1968442373 cites W1551558367 @default.
• W1968442373 cites W1983936492 @default.
• W1968442373 cites W1997937012 @default.
• W1968442373 cites W1998947189 @default.
• W1968442373 cites W2001535795 @default.
• W1968442373 cites W2002015501 @default.
• W1968442373 cites W2007522014 @default.
• W1968442373 cites W2011026340 @default.
• W1968442373 cites W2018038125 @default.
• W1968442373 cites W2019342319 @default.
• W1968442373 cites W2026794152 @default.
• W1968442373 cites W2027268907 @default.
• W1968442373 cites W2030467216 @default.
• W1968442373 cites W2043107339 @default.
• W1968442373 cites W2044386300 @default.
• W1968442373 cites W2047502557 @default.
• W1968442373 cites W2051950808 @default.
• W1968442373 cites W2061559645 @default.
• W1968442373 cites W2065525516 @default.
• W1968442373 cites W2065793986 @default.
• W1968442373 cites W2071392945 @default.
• W1968442373 cites W2090882796 @default.
• W1968442373 cites W2106970047 @default.
• W1968442373 cites W2168492702 @default.
• W1968442373 cites W2339315384 @default.
• W1968442373 cites W2342324183 @default.
• W1968442373 doi "https://doi.org/10.1016/s0735-1097(87)80242-5" @default.
• W1968442373 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3104435" @default.
• W1968442373 hasPublicationYear "1987" @default.
• W1968442373 type Work @default.
• W1968442373 sameAs 1968442373 @default.
• W1968442373 citedByCount "42" @default.
• W1968442373 countsByYear W19684423732013 @default.
• W1968442373 countsByYear W19684423732014 @default.
• W1968442373 crossrefType "journal-article" @default.
• W1968442373 hasAuthorship W1968442373A5039521418 @default.
• W1968442373 hasAuthorship W1968442373A5039838157 @default.
• W1968442373 hasAuthorship W1968442373A5041120210 @default.
• W1968442373 hasAuthorship W1968442373A5041791481 @default.
• W1968442373 hasAuthorship W1968442373A5082162481 @default.
• W1968442373 hasAuthorship W1968442373A5087673809 @default.
• W1968442373 hasBestOaLocation W19684423731 @default.
• W1968442373 hasConcept C120770815 @default.
• W1968442373 hasConcept C126322002 @default.
• W1968442373 hasConcept C139940330 @default.
• W1968442373 hasConcept C146556889 @default.
• W1968442373 hasConcept C164705383 @default.
• W1968442373 hasConcept C178853913 @default.
• W1968442373 hasConcept C205679159 @default.
• W1968442373 hasConcept C2778198053 @default.
• W1968442373 hasConcept C2780940725 @default.
• W1968442373 hasConcept C42219234 @default.
• W1968442373 hasConcept C58245268 @default.
• W1968442373 hasConcept C71924100 @default.
• W1968442373 hasConcept C84393581 @default.
• W1968442373 hasConcept C98274493 @default.
• W1968442373 hasConceptScore W1968442373C120770815 @default.
• W1968442373 hasConceptScore W1968442373C126322002 @default.
• W1968442373 hasConceptScore W1968442373C139940330 @default.
• W1968442373 hasConceptScore W1968442373C146556889 @default.
• W1968442373 hasConceptScore W1968442373C164705383 @default.
• W1968442373 hasConceptScore W1968442373C178853913 @default.
• W1968442373 hasConceptScore W1968442373C205679159 @default.
• W1968442373 hasConceptScore W1968442373C2778198053 @default.
• W1968442373 hasConceptScore W1968442373C2780940725 @default.
• W1968442373 hasConceptScore W1968442373C42219234 @default.
• W1968442373 hasConceptScore W1968442373C58245268 @default.
• W1968442373 hasConceptScore W1968442373C71924100 @default.
• W1968442373 hasConceptScore W1968442373C84393581 @default.
• W1968442373 hasConceptScore W1968442373C98274493 @default.
• W1968442373 hasIssue "4" @default.
• W1968442373 hasLocation W19684423731 @default.
• W1968442373 hasLocation W19684423732 @default.
• W1968442373 hasOpenAccess W1968442373 @default.
• W1968442373 hasPrimaryLocation W19684423731 @default.
• W1968442373 hasRelatedWork W1978502602 @default.
• W1968442373 hasRelatedWork W2010738716 @default.
• W1968442373 hasRelatedWork W2021468243 @default.
• W1968442373 hasRelatedWork W2079969916 @default.
• W1968442373 hasRelatedWork W2362896919 @default.
• W1968442373 hasRelatedWork W2411173000 @default.
• W1968442373 hasRelatedWork W2412678960 @default.
• W1968442373 hasRelatedWork W2421076670 @default.
• W1968442373 hasRelatedWork W4385716628 @default.
• W1968442373 hasRelatedWork W80830818 @default.
• W1968442373 hasVolume "9" @default.
• W1968442373 isParatext "false" @default.

• next