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- W1968442858 abstract "Fosfomycin is a gram positive and gram negative antibiotic that contains an asymmetric epoxide. An enzyme library was screened for its ability to reduce dimethyl(1-chloro-2-oxopropyl)phosphonate to the corresponding asymmetric chlorohydrin. Homology models were built in MOE, which were shown to accurately model the enzyme–substrate complex displaying the stereoselectivity that we observed. Two enzymes, YDR368w and YHR104w, were chosen for the scale up and synthesis of fosfomycin and its trans-(1S,2S)-diastereomer." @default.
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- W1968442858 date "2011-10-01" @default.
- W1968442858 modified "2023-10-18" @default.
- W1968442858 title "Asymmetric synthesis of (−)-fosfomycin and its trans-(1S,2S)-diastereomer using a biocatalytic reduction as the key step" @default.
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- W1968442858 doi "https://doi.org/10.1016/j.tetasy.2011.10.009" @default.
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