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• W1968450930 endingPage "2127" @default.
• W1968450930 startingPage "2122" @default.
• W1968450930 abstract "Abstract Turns are secondary‐structure elements that are omnipresent in natively folded polypeptide chains. A large variety of four‐residue β‐turns exist, which differ mainly in the backbone dihedral angle values of the two central residues i +1 and i +2. The βVI‐type turns are of particular biological interest because the i +2 residue is always a proline in the cis conformation and might thus serve as target of peptidyl prolyl cis / trans isomerases (PPIases). We have designed cyclic hexapeptides containing two proline residues that predominantly adopt the cis conformation in aqueous solution. NMR data and MD calculations indicated that the cyclic peptide sequences c‐(‐ D Xaa‐Ser‐Pro‐ D Xaa‐Lys‐Pro‐) result in highly symmetric backbone structures when both prolines are in the cis conformation and the D ‐amino acids are either alanine or phenylalanine residues. Replacement of the serine residue either by phosphoserine or by tyrosine compromises this symmetry, but further increases the cis conformation content of both prolines. As a result, we obtained a cyclic hexapeptide that exists almost exclusively as the cis ‐Pro/ cis ‐Pro conformer but shows no cis / trans interconversion even in the presence of the PPIase Pin1, apparently due to an energetically quite favorable but highly restricted conformational space." @default.
• W1968450930 created "2016-06-24" @default.
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• W1968450930 date "2012-09-11" @default.
• W1968450930 modified "2023-10-17" @default.
• W1968450930 title "Design of Cyclic Peptides Featuring Proline Predominantly in the<i>cis</i>Conformation under Physiological Conditions" @default.
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• W1968450930 doi "https://doi.org/10.1002/cbic.201200366" @default.
• W1968450930 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22969011" @default.
• W1968450930 hasPublicationYear "2012" @default.
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