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- W1968456747 abstract "In the urine of subjects given an oral dose of spironolactone [3-(3-oxo-7α-acetylthio-17β-hydroxy-4-androsten-17α-y1)propionic acid γ-lactone], six metabolites have been detected. One of the major metabolites was found to be the previously characterized de-thioacetylated compound, 3-(3-oxo-17β-hydroxy-4,6-androstadien-17α-y1)propionic acid γ-lactone (canrenone). Besides this a new major sulfur-containing metabolite has been isolated and identified as 3-(3-oxo-7α-methylsulfinyl-6β,17β-dihydroxy-4-androsten-17α-y1)propionic acid γ-lactone. This structural assignment was based on detailed analysis of its IR, NMR and UV spectra as well as comparison of its physical constants and chromatographic (TLC and GLC) characteristics with a synthetic sample. The three minor metabolites were found to be very labile and were readily converted to canrenone." @default.
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- W1968456747 date "1972-07-01" @default.
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- W1968456747 title "Isolation and identification of novel sulfur-containing metabolites of spironolactone (Aldactone®)" @default.
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- W1968456747 doi "https://doi.org/10.1016/0039-128x(72)90117-1" @default.
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