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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968458265> ?p ?o ?g. }

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• W1968458265 abstract "Phosphatidic acid (PA) is a potent second messenger arising from growth factor-induced stimulation of phospholipase D which hydrolyses phosphatidylcholine. PA is hydrolysed to diacylglycerol by PA phosphohydrolase (PAP) which exists in two forms: PAP-1 and PAP-2. In rat hepatocyte cultures, overnight (20h) incubation with transforming growth factor (TGF) β (1ng/ml) increased PAP-1 activity two-fold. This effect was concentration and time dependent and was greatest at low cell density. The TGFβ effect on PAP-1 was additive to stimulation induced by dexamethasone but not by glucagon and it reversed the inhibition by insulin. Epidermal growth factor had no effect on PAP-1 activity. None of the above hormones or growth factors affected the subcellular distribution of PAP-1. Stimulation of PAP-1 by TGFβ may be involved in mediating some of its biological effects." @default.
• W1968458265 created "2016-06-24" @default.
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• W1968458265 date "1997-01-01" @default.
• W1968458265 modified "2023-10-18" @default.
• W1968458265 title "Transforming Growth Factor β Increases the Activity of Phosphatidate Phosphohydrolase-1 in Rat Hepatocytes" @default.
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• W1968458265 doi "https://doi.org/10.1006/bbrc.1996.5965" @default.
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