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• W1968461135 abstract "The human Y chromosome, because it is enriched in repetitive DNA, has been very intractable to genetic and molecular analyses. There is no previous evidence for developmental stage- and testis-specific transcription from the male-specific region of the Y (MSY). Here, we present evidence for the first time for a developmental stage- and testis-specific transcription from MSY distal heterochromatic block. We isolated two novel RNAs, which localize to Yq12 in multiple copies, show testis-specific expression, and lack active X-homologs. Experimental evidence shows that one of the above Yq12 noncoding RNAs (ncRNAs) trans -splices with CDC2L2 mRNA from chromosome 1p36.3 locus to generate a testis-specific chimeric β sv13 isoform. This 67-nt 5′UTR provided by the Yq12 transcript contains within it a Y box protein-binding CCAAT motif, indicating translational regulation of the β sv13 isoform in testis. This is also the first report of trans -splicing between a Y chromosomal and an autosomal transcript." @default.
• W1968461135 created "2016-06-24" @default.
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• W1968461135 date "2006-11-09" @default.
• W1968461135 modified "2023-09-27" @default.
• W1968461135 title "Novel noncoding RNA from human Y distal heterochromatic block (Yq12) generates testis-specific chimeric <i>CDC2L2</i>" @default.
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• W1968461135 doi "https://doi.org/10.1101/gr.5155706" @default.
• W1968461135 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1832090" @default.
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