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- W1968461504 abstract "Caffeine, theophylline or aminophylline were administered chronically to rats of both sexes, in the weight range 30-245 g. Self-injurious behaviour was noted only rarely in Wistar rats allowed free access to food, but developed over 3 to 4 weeks in half of the animals given a restricted diet of about one third of the intake of control rats. Fischer rats showed self-injurious behaviour more readily, 87% of animals showing signs within 9 days even on an ad lib diet. It is suggested that Fischer rats treated with methylxanthines may provide a model of the Lesch-Nyhan syndrome. Behavioural observations made during the period of methylxanthine treatment suggest that an activation of both the dopamine and 5-hydroxytryptamine neurone systems may be produced. Further work will seek a relationship between these systems and self-injurious behaviour." @default.
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- W1968461504 date "1981-06-01" @default.
- W1968461504 modified "2023-09-25" @default.
- W1968461504 title "Chronic methylxanthine treatment in rats: A comparison of Wistar and Fischer 344 strains" @default.
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- W1968461504 doi "https://doi.org/10.1016/0091-3057(81)90368-3" @default.
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