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• W1968462093 abstract "Vox SanguinisVolume 67, Issue s3 p. 49-52 IMPACT OF RECOMBINANT FACTOR VIII! ON HEMOPHILIA CARE PIER MANNUCCIO MANNUCCI, PIER MANNUCCIO MANNUCCI Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and Institute of Internal Medicine University of Milan ItalySearch for more papers by this author PIER MANNUCCIO MANNUCCI, PIER MANNUCCIO MANNUCCI Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and Institute of Internal Medicine University of Milan ItalySearch for more papers by this author First published: July 1994 https://doi.org/10.1111/j.1423-0410.1994.tb04543.xCitations: 3AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Toole, JJ, Knopf, JL, Wozney, JM, Sultzman, LA, Buecker, JL, Pittman, DD, Kaufman, RJ, Brown, E, Shoemaker, CB, Orr, EC, Amphlett, GW, Foster, B, Coe, ML, Knutson, GJ, Fass, DN, Hewick, RM: Molecular cloning of a cDNA encoding human antihemophilic factor. Nature 1984; 312: 342–347. 2 Wood, WI, Capon, DJ, Simonsen, CC, Eaton, DL, Gitschier, J, Keyt, B, Seeburg, PH, Smith, DH, Hollingshead, P, Wion, K, Delwart, E, Tuddenham, EGD, Vehar, GA, Lawn, RM: Expression of active human factor VIII from recombinant DNA clones. Nature 1984; 312: 330–337. 3 Kaufman, RJ, Wasley, LC, Dorner, AJ: Synthesis, processing and secretion of recombinant human factor VIII expressed in mammalian cells. J Biol Chem 1988; 263: 6351–6362. 4 Klein, U: Production and characterization of recombinant factor VIII. Sem Hematol 1991; 28 (suppl. 1): 17–21. 5 Fournel, M: Preclinical and in vivo studies of rFVIII. Sem Hematol 1990; 28 (suppl. 1): 22–26. 6 Giles, AR, Tinlin, S, Hoogendoorn, H, Fournel, MA, Ng, P, Pancham, N: In vivo characterization of recombinant factor VIII in a canine model of hemophilia A (factor VIII deficiency). Blood 1988; 72, 335–342. 7 Mikaelsson, M, Eriksson, B, Lind, P, Lindner, E, Ljungqvist, A, Lofstrom, A, Sandbory, H, Wiken, M. Manufacturing and characterization of a new B-domain delated recombinant factor VIII, r-VIIISQ. Thrombos Haemostas 1993; 69: 1205. 8 White, GC, II, Mc Millan, CW, Kingdon, HS, Shoemaker, CB: Use of recombinant antihemophilic factor in the treatment of two patients with classic hemophilia. N Engl J Med 1989; 320, 166–170. 9 Schwartz, RS, Abildgaard, C, Aledort, LM, Arkin, S, Bloom, A, Brackmann, H, Brettler, D, Dietrich, S, Egli, J, Hilgartner, M, Inwood, M, Kasper, C, Kernoff, P, Levine, P, Lusher, JM, Mannucci, PM, Rose, E, Scharrer, I: Human recombinant DNA derived antihemophilic factor (factor VIII) in the treatment of hemophilia A. N Engl J Med 1990; 323: 1800–1805. 10 Goldsmith JC and the Recombinate Study Group: Clinical trial of Recombinate: safety and efficacy of a genetically engineered anti-hemophilic factor in previously treated patients. Blood 1991; 78 (suppl. 1) 64a. 11 Berntorp, E, Johnsson, H, Lethagen, S, Lindstedt, Tengborn L. B- domain deletion does not affect the kinetics of factor VIII. A bioequivalence study of r-VIII SQ Pharrnacia versus p-VIII. 21st Internation Congress of the World Federation of Hemophilia (Mexico City) Abstract book, p 1994. 12 Lusher, JM, Arkin, S, Abildgaard, CF, Schwartz, RS and: The Kogenate Previously Untreated Patients Study Group Recombinant factor VIII for the treatment of previously untreated patients with hemophilia A. Safety, efficacy and development of inhibitors. N Engl J Med 1993; 328: 453–459. 13 Bray, GL, Lee, ML, Courter, S, Gomperts, E, and: The Kogenate Previously Untreated Patients Study Group clinical studies with recombinant factor VIII (Recombinate) in previously untreated patients with severe hemophilia A. Blood 1993; 82 (suppl. 1), 446a. 14 Lusher, JM: Viral safety and inhibitor development associated with monoclonal antibody purified FVIIIC. Ann Hematol 1991; 62: 1–4. 15 Ehrenforth, S, Kreuz, W, Scharrer, I, Linde, R, Funk, M, Gungor, T, Brackhardt, B, Kornhuber, B: Incidence of development of factor VIII and factor IX inhibitor in hemophiliacs. Lancet 1992; 339: 594–598. 16 Addiego, J, Kasper, C, Abildgaard, C, Hilgartner, M, Lusher, J, Glader, B, Aledort, L. Frequency of inhibitors development in hemophiliacs treated with low-purity factor VIII. Lancet 1993; 342: 462–464. Citing Literature Volume67, Issues3July 1994Pages 49-52 ReferencesRelatedInformation" @default.
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