Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968463506> ?p ?o ?g. }
- W1968463506 endingPage "313" @default.
- W1968463506 startingPage "305" @default.
- W1968463506 abstract "Background: The renin–angiotensin system (RAS) is regarded as one of the most important regulatory systems for cardiovascular homeostasis. In this study, we investigated associations of the five genetic polymorphisms in the RAS and presence of coronary artery disease (CAD) in type 2 diabetes. Methods: Genotyping was performed by polymerase chain reaction–restriction fragment length polymorphism analysis. We used the generalised multifactor dimensionality reduction (GMDR) method to identify gene–gene interactions. Results: The D allele in the ACE gene was significantly more frequent in type 2 diabetic patients with CAD (p = 0.04). In multivariate logistic regression analysis, the DD genotype was associated with a significantly increased risk of CAD (p = 0.044). 1675G/A variant in the AT2R gene was found to be associated with CAD in female subjects with type 2 diabetes (p = 0.025). The three other polymorphisms of the RAS do not seem to influence the development of CAD in type 2 diabetes. No significant gene–gene interaction for any combinations of genotypes was found in the GMDR method. Conclusion: The DD variant of the ACE gene polymorphism is associated with increased risk of developing CAD in Chinese patients with type 2 diabetes. A slight impact of AT2R 1675G/A polymorphism on CAD was found only in female diabetic patients." @default.
- W1968463506 created "2016-06-24" @default.
- W1968463506 creator A5009831782 @default.
- W1968463506 creator A5024611619 @default.
- W1968463506 creator A5025420693 @default.
- W1968463506 creator A5028961728 @default.
- W1968463506 creator A5041934647 @default.
- W1968463506 creator A5047917374 @default.
- W1968463506 creator A5055229683 @default.
- W1968463506 creator A5065292706 @default.
- W1968463506 creator A5065689034 @default.
- W1968463506 creator A5080309923 @default.
- W1968463506 creator A5082793597 @default.
- W1968463506 creator A5091220141 @default.
- W1968463506 date "2012-02-16" @default.
- W1968463506 modified "2023-09-26" @default.
- W1968463506 title "Association between polymorphisms of the renin–angiotensin system and coronary artery disease in Chinese patients with type 2 diabetes" @default.
- W1968463506 cites W1522117041 @default.
- W1968463506 cites W1528710614 @default.
- W1968463506 cites W1966038517 @default.
- W1968463506 cites W1967095895 @default.
- W1968463506 cites W1970493260 @default.
- W1968463506 cites W1976634586 @default.
- W1968463506 cites W1982645590 @default.
- W1968463506 cites W1983434801 @default.
- W1968463506 cites W1986231645 @default.
- W1968463506 cites W1986327051 @default.
- W1968463506 cites W1986727164 @default.
- W1968463506 cites W1995429630 @default.
- W1968463506 cites W2003139131 @default.
- W1968463506 cites W2006394148 @default.
- W1968463506 cites W2010743737 @default.
- W1968463506 cites W2013688320 @default.
- W1968463506 cites W2018368325 @default.
- W1968463506 cites W2018941939 @default.
- W1968463506 cites W2031150814 @default.
- W1968463506 cites W2043075162 @default.
- W1968463506 cites W2043600435 @default.
- W1968463506 cites W2051836135 @default.
- W1968463506 cites W2054837618 @default.
- W1968463506 cites W2067060165 @default.
- W1968463506 cites W2072262664 @default.
- W1968463506 cites W2074446987 @default.
- W1968463506 cites W2098770902 @default.
- W1968463506 cites W2100767767 @default.
- W1968463506 cites W2122936122 @default.
- W1968463506 cites W2127423576 @default.
- W1968463506 cites W2149148526 @default.
- W1968463506 cites W2150045656 @default.
- W1968463506 cites W2156835140 @default.
- W1968463506 cites W2163216920 @default.
- W1968463506 cites W2163610648 @default.
- W1968463506 cites W4320301345 @default.
- W1968463506 doi "https://doi.org/10.1177/1470320311435533" @default.
- W1968463506 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22345093" @default.
- W1968463506 hasPublicationYear "2012" @default.
- W1968463506 type Work @default.
- W1968463506 sameAs 1968463506 @default.
- W1968463506 citedByCount "13" @default.
- W1968463506 countsByYear W19684635062012 @default.
- W1968463506 countsByYear W19684635062014 @default.
- W1968463506 countsByYear W19684635062015 @default.
- W1968463506 countsByYear W19684635062016 @default.
- W1968463506 countsByYear W19684635062017 @default.
- W1968463506 countsByYear W19684635062018 @default.
- W1968463506 countsByYear W19684635062019 @default.
- W1968463506 countsByYear W19684635062022 @default.
- W1968463506 crossrefType "journal-article" @default.
- W1968463506 hasAuthorship W1968463506A5009831782 @default.
- W1968463506 hasAuthorship W1968463506A5024611619 @default.
- W1968463506 hasAuthorship W1968463506A5025420693 @default.
- W1968463506 hasAuthorship W1968463506A5028961728 @default.
- W1968463506 hasAuthorship W1968463506A5041934647 @default.
- W1968463506 hasAuthorship W1968463506A5047917374 @default.
- W1968463506 hasAuthorship W1968463506A5055229683 @default.
- W1968463506 hasAuthorship W1968463506A5065292706 @default.
- W1968463506 hasAuthorship W1968463506A5065689034 @default.
- W1968463506 hasAuthorship W1968463506A5080309923 @default.
- W1968463506 hasAuthorship W1968463506A5082793597 @default.
- W1968463506 hasAuthorship W1968463506A5091220141 @default.
- W1968463506 hasBestOaLocation W19684635061 @default.
- W1968463506 hasConcept C104317684 @default.
- W1968463506 hasConcept C126322002 @default.
- W1968463506 hasConcept C134018914 @default.
- W1968463506 hasConcept C135763542 @default.
- W1968463506 hasConcept C149737253 @default.
- W1968463506 hasConcept C151956035 @default.
- W1968463506 hasConcept C153209595 @default.
- W1968463506 hasConcept C180754005 @default.
- W1968463506 hasConcept C198710026 @default.
- W1968463506 hasConcept C25249476 @default.
- W1968463506 hasConcept C27016395 @default.
- W1968463506 hasConcept C2777180221 @default.
- W1968463506 hasConcept C2778213512 @default.
- W1968463506 hasConcept C31467283 @default.
- W1968463506 hasConcept C54355233 @default.
- W1968463506 hasConcept C555293320 @default.
- W1968463506 hasConcept C60644358 @default.