FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968470147> ?p ?o ?g. }

• W1968470147 endingPage "52" @default.
• W1968470147 startingPage "48" @default.
• W1968470147 abstract "Renin, which catalyzes the initial proteolytic cleavage reaction in the production of angiotensins, is first synthesized as a zymogen, prorenin, and requires the proteolytic removal of an amino‐terminal prosegment for activation in vivo. The lysosomal hydrolase cathepsin B has been proposed as a prorenin processing enzyme based on reports of its co‐localization with renin in the secretory granules of certain tissues and its ability to activate prorenin in vitro. In the current study, scanning mutagenesis was used to identify the amino acids which determine the site selectivity of prorenin cleavage by human cathepsin B in vitro. Co‐expression assays in AtT‐20 cells were also used to test for the ability of cathepsin B to cleave human prorenin within cells. Our results suggest that a basic lysine residue at the −2 position from the cleavage site is required for cathepsin B cleavage of prorenin in vitro and that the structure of prorenin itself may account for the selection of the proper cleavage site. In addition, although cathepsin B appears to be correctly sorted to lysosomes, the enzyme exhibits prorenin processing activity in transfected AtT‐20 cells, raising the question of the cellular localization in which the processing event occurs." @default.
• W1968470147 created "2016-06-24" @default.
• W1968470147 creator A5063192986 @default.
• W1968470147 creator A5085315426 @default.
• W1968470147 date "1999-01-22" @default.
• W1968470147 modified "2023-09-25" @default.
• W1968470147 title "Prorenin processing by cathepsin B in vitro and in transfected cells" @default.
• W1968470147 cites W1482788894 @default.
• W1968470147 cites W1492834300 @default.
• W1968470147 cites W1536136278 @default.
• W1968470147 cites W1540687701 @default.
• W1968470147 cites W1553448789 @default.
• W1968470147 cites W1568907619 @default.
• W1968470147 cites W1586793828 @default.
• W1968470147 cites W1750871115 @default.
• W1968470147 cites W1881432776 @default.
• W1968470147 cites W1895906686 @default.
• W1968470147 cites W1965174263 @default.
• W1968470147 cites W1975552502 @default.
• W1968470147 cites W1983917496 @default.
• W1968470147 cites W1993552704 @default.
• W1968470147 cites W1998591058 @default.
• W1968470147 cites W2009817183 @default.
• W1968470147 cites W2020949076 @default.
• W1968470147 cites W2026167342 @default.
• W1968470147 cites W2031254987 @default.
• W1968470147 cites W2042381978 @default.
• W1968470147 cites W2042482991 @default.
• W1968470147 cites W2050097502 @default.
• W1968470147 cites W2050638929 @default.
• W1968470147 cites W2051407773 @default.
• W1968470147 cites W2052408753 @default.
• W1968470147 cites W2080942310 @default.
• W1968470147 cites W2088191210 @default.
• W1968470147 cites W2091951007 @default.
• W1968470147 cites W2093901721 @default.
• W1968470147 cites W2105657148 @default.
• W1968470147 cites W2107263775 @default.
• W1968470147 cites W2113457827 @default.
• W1968470147 cites W2127003822 @default.
• W1968470147 cites W2136903164 @default.
• W1968470147 cites W2138226685 @default.
• W1968470147 cites W2146721491 @default.
• W1968470147 cites W2324247492 @default.
• W1968470147 cites W2332801349 @default.
• W1968470147 cites W2472200701 @default.
• W1968470147 cites W2886017093 @default.
• W1968470147 cites W4211064734 @default.
• W1968470147 cites W4237882566 @default.
• W1968470147 doi "https://doi.org/10.1016/s0014-5793(98)01672-x" @default.
• W1968470147 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9928950" @default.
• W1968470147 hasPublicationYear "1999" @default.
• W1968470147 type Work @default.
• W1968470147 sameAs 1968470147 @default.
• W1968470147 citedByCount "49" @default.
• W1968470147 countsByYear W19684701472012 @default.
• W1968470147 countsByYear W19684701472013 @default.
• W1968470147 countsByYear W19684701472014 @default.
• W1968470147 countsByYear W19684701472015 @default.
• W1968470147 countsByYear W19684701472017 @default.
• W1968470147 countsByYear W19684701472018 @default.
• W1968470147 countsByYear W19684701472020 @default.
• W1968470147 countsByYear W19684701472021 @default.
• W1968470147 countsByYear W19684701472022 @default.
• W1968470147 crossrefType "journal-article" @default.
• W1968470147 hasAuthorship W1968470147A5063192986 @default.
• W1968470147 hasAuthorship W1968470147A5085315426 @default.
• W1968470147 hasConcept C104317684 @default.
• W1968470147 hasConcept C151701858 @default.
• W1968470147 hasConcept C151730666 @default.
• W1968470147 hasConcept C153911025 @default.
• W1968470147 hasConcept C167844969 @default.
• W1968470147 hasConcept C173633252 @default.
• W1968470147 hasConcept C175156509 @default.
• W1968470147 hasConcept C181199279 @default.
• W1968470147 hasConcept C182220744 @default.
• W1968470147 hasConcept C185592680 @default.
• W1968470147 hasConcept C202751555 @default.
• W1968470147 hasConcept C2778775115 @default.
• W1968470147 hasConcept C2780034444 @default.
• W1968470147 hasConcept C28021979 @default.
• W1968470147 hasConcept C34695024 @default.
• W1968470147 hasConcept C43369102 @default.
• W1968470147 hasConcept C51618164 @default.
• W1968470147 hasConcept C54009773 @default.
• W1968470147 hasConcept C55493867 @default.
• W1968470147 hasConcept C78553746 @default.
• W1968470147 hasConcept C81216549 @default.
• W1968470147 hasConcept C86803240 @default.
• W1968470147 hasConceptScore W1968470147C104317684 @default.
• W1968470147 hasConceptScore W1968470147C151701858 @default.
• W1968470147 hasConceptScore W1968470147C151730666 @default.
• W1968470147 hasConceptScore W1968470147C153911025 @default.
• W1968470147 hasConceptScore W1968470147C167844969 @default.
• W1968470147 hasConceptScore W1968470147C173633252 @default.
• W1968470147 hasConceptScore W1968470147C175156509 @default.
• W1968470147 hasConceptScore W1968470147C181199279 @default.
• W1968470147 hasConceptScore W1968470147C182220744 @default.

• next