Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968472714> ?p ?o ?g. }
- W1968472714 endingPage "842" @default.
- W1968472714 startingPage "833" @default.
- W1968472714 abstract "The expression of N-cadherin, characteristic of various cancers, very often leads to changes in the cells' adhesive properties. Thus, we sought to find out if N-cadherin expressed in various, but cancer-related cells, differs in its functional properties that could contribute to variations in cells' phenotypes. In our work, measurements of an unbinding force of a single N-cadherin molecule, probed with the same antibody both on a surface of living non-malignant (HCV29) and malignant cells (T24) of bladder cancer, were carried out with the use of an atomic force microscopy. The results show the enhanced N-cadherin level in T24 malignant cells (8.7% vs. 3.6% obtained for non-malignant one), confirmed by the Western blot and the immunohistochemical staining. The effect was accompanied by changes in unbinding properties of an individual N-cadherin molecule. Lower unbinding force values (26.1 ± 7.1 pN) in non-malignant cells reveal less stable N-cadherin complexes, as compared to malignant cells (61.7 ± 14.6 pN). This suggests the cancer-related changes in a structure of the binding site of the antibody, located at the extracellular domain of N-cadherin. Copyright © 2011 John Wiley & Sons, Ltd." @default.
- W1968472714 created "2016-06-24" @default.
- W1968472714 creator A5007040247 @default.
- W1968472714 creator A5032742421 @default.
- W1968472714 creator A5042976399 @default.
- W1968472714 creator A5057799391 @default.
- W1968472714 creator A5066920032 @default.
- W1968472714 creator A5068128072 @default.
- W1968472714 creator A5082318908 @default.
- W1968472714 creator A5087466733 @default.
- W1968472714 creator A5088017479 @default.
- W1968472714 date "2011-07-26" @default.
- W1968472714 modified "2023-10-01" @default.
- W1968472714 title "Characterization of N-cadherin unbinding properties in non-malignant (HCV29) and malignant (T24) bladder cells" @default.
- W1968472714 cites W1487498644 @default.
- W1968472714 cites W1936593340 @default.
- W1968472714 cites W1964242194 @default.
- W1968472714 cites W1970516397 @default.
- W1968472714 cites W1972853255 @default.
- W1968472714 cites W1974115398 @default.
- W1968472714 cites W1978932874 @default.
- W1968472714 cites W1980441330 @default.
- W1968472714 cites W1981538228 @default.
- W1968472714 cites W1987473368 @default.
- W1968472714 cites W1987729382 @default.
- W1968472714 cites W1993004731 @default.
- W1968472714 cites W1994979141 @default.
- W1968472714 cites W1996764730 @default.
- W1968472714 cites W2002769350 @default.
- W1968472714 cites W2008257352 @default.
- W1968472714 cites W2013797019 @default.
- W1968472714 cites W2020166810 @default.
- W1968472714 cites W2021916807 @default.
- W1968472714 cites W2028586185 @default.
- W1968472714 cites W2044332414 @default.
- W1968472714 cites W2053144508 @default.
- W1968472714 cites W2053443235 @default.
- W1968472714 cites W2062234837 @default.
- W1968472714 cites W2065604700 @default.
- W1968472714 cites W2069469763 @default.
- W1968472714 cites W2069629599 @default.
- W1968472714 cites W2073079990 @default.
- W1968472714 cites W2079508597 @default.
- W1968472714 cites W2082578520 @default.
- W1968472714 cites W2082905439 @default.
- W1968472714 cites W2084555620 @default.
- W1968472714 cites W2088321333 @default.
- W1968472714 cites W2092994838 @default.
- W1968472714 cites W2105209624 @default.
- W1968472714 cites W2106059993 @default.
- W1968472714 cites W2117502386 @default.
- W1968472714 cites W2127920357 @default.
- W1968472714 cites W2136949471 @default.
- W1968472714 cites W2139644888 @default.
- W1968472714 cites W2139896193 @default.
- W1968472714 cites W2146654096 @default.
- W1968472714 cites W2162281220 @default.
- W1968472714 cites W2169671503 @default.
- W1968472714 cites W2169882872 @default.
- W1968472714 cites W2171284757 @default.
- W1968472714 cites W2172172421 @default.
- W1968472714 cites W2242263946 @default.
- W1968472714 cites W2326133032 @default.
- W1968472714 cites W3150248096 @default.
- W1968472714 cites W4211224216 @default.
- W1968472714 cites W4239899168 @default.
- W1968472714 doi "https://doi.org/10.1002/jmr.1123" @default.
- W1968472714 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21812057" @default.
- W1968472714 hasPublicationYear "2011" @default.
- W1968472714 type Work @default.
- W1968472714 sameAs 1968472714 @default.
- W1968472714 citedByCount "12" @default.
- W1968472714 countsByYear W19684727142014 @default.
- W1968472714 countsByYear W19684727142015 @default.
- W1968472714 countsByYear W19684727142017 @default.
- W1968472714 countsByYear W19684727142018 @default.
- W1968472714 countsByYear W19684727142020 @default.
- W1968472714 countsByYear W19684727142022 @default.
- W1968472714 countsByYear W19684727142023 @default.
- W1968472714 crossrefType "journal-article" @default.
- W1968472714 hasAuthorship W1968472714A5007040247 @default.
- W1968472714 hasAuthorship W1968472714A5032742421 @default.
- W1968472714 hasAuthorship W1968472714A5042976399 @default.
- W1968472714 hasAuthorship W1968472714A5057799391 @default.
- W1968472714 hasAuthorship W1968472714A5066920032 @default.
- W1968472714 hasAuthorship W1968472714A5068128072 @default.
- W1968472714 hasAuthorship W1968472714A5082318908 @default.
- W1968472714 hasAuthorship W1968472714A5087466733 @default.
- W1968472714 hasAuthorship W1968472714A5088017479 @default.
- W1968472714 hasConcept C102951782 @default.
- W1968472714 hasConcept C104317684 @default.
- W1968472714 hasConcept C121608353 @default.
- W1968472714 hasConcept C126322002 @default.
- W1968472714 hasConcept C127716648 @default.
- W1968472714 hasConcept C142724271 @default.
- W1968472714 hasConcept C1491633281 @default.
- W1968472714 hasConcept C149402561 @default.
- W1968472714 hasConcept C159654299 @default.