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- W1968473165 abstract "Rabbit knee articular cartilage was studied after the joint was submitted to immobilization, running or increased weight bearing for 24–27 days. Immobilization with a plastic splint reduced the fraction of proteoglycans not extractable with 4 M guanidinium chloride (GdnHCl). In the immobilized joints the chondroitin sulfate content was elevated as calculated from the galactosamine/glucosamine ratio. The ability of these proteoglycans to reform aggregates with endogenous hyaluronic acid in Sepharose CL-2B chromatography was reduced. Increased exercise was associated with an elevation of proteoglycans extractable with 4 M GdnHCl. The increased weight bearing occurring in the contralateral knee elevated the content of proteoglycans not extractable with 4 M GdnHCl. Other effects of weight bearing included increased glucosamine concentration, suggesting accumulation of keratan sulfate-rich proteoglycans, and an elevated hydroxyproline concentration." @default.
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- W1968473165 date "1983-01-01" @default.
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- W1968473165 title "Proteoglycan Alterations in Rabbit Knee Articular Cartilage Following Physical Exercise and Immobilization" @default.
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- W1968473165 doi "https://doi.org/10.3109/03008208309015010" @default.
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