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- W1968479032 abstract "Abstract To overcome various difficulties associated with the replacement of drug therapy for pancreatic insufficiency, film-coated tablets releasing the drug in front of the pylorus were developed and studied in dogs using a series of X-rays. The tablets, containing pregelatinized starch or carmellose as a disintegrant, were coated with cellulose acetate phthalate (CAP), hydroxypropyl methylcellulose phthalate (HPMCP) or methacrylic acid co-polymer (Eudragit L) combined with the soluble polymers, hydroxypropyl methylcellulose (HPMC) or methacrylate esters co-polymer (Eudragit E). Sustained-release tablets were coated with ethyl cellulose (EC) containing small amounts of HPMC. When administered with food, controlled drug release was achieved in front of the pylorus with conventional enteric materials if the tablets also contained a suitable disintegrant. EC-HPMC-coated tablets act as a prolonged action formulation, releasing the drug for up to 5–7 h in front of the pylorus and thereafter in the intestine. As demonstrated in these dog studies, it should therefore be possible to develop sustained-release formulations which release pancreatic enzymes for a prolonged period of time in a site favourable for their digestive function." @default.
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- W1968479032 date "1988-12-01" @default.
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- W1968479032 title "Formulations releasing the drug proximal to the pylorus in the dog" @default.
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- W1968479032 doi "https://doi.org/10.1016/0378-5173(88)90247-5" @default.
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