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- W1968479908 abstract "In their recent Review article (A pathophysiological framework of hippocampal dysfunction in ageing and disease. Nature Rev. Neurosci. 12, 585–601 (2011))1, Small et al. present a compelling framework for differentiating hippocampal disorders based on the selective vulnerability of hippocampal subregions using recent neuroimaging findings. This framework stimulates thoughts about how (dys)function of distinct hippocampal subregions relates to disease and how it can be assessed in the future using high-resolution structural and functional MRI. The impact this pathophysiological framework has on clinical practice depends to a great extent on the availability, quality and reliability of methods to discern hippocampal subregions in vivo. In many hospitals, 3-Tesla MRI scanners have become the standard for obtaining high-resolution in vivo brain images, and the introduction of 7-Tesla MRI may lead to a revolutionary increase in image detail. Nonetheless, accurately measuring hippocampal subregions with in vivo MRI has proved to be challenging2. In this Correspondence, we illustrate how human in vivo MRI acquisition and image post-processing methods need to advance to reliably measure and differentiate hippocampal subregions." @default.
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- W1968479908 date "2011-12-20" @default.
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- W1968479908 title "Imaging hippocampal subregions with in vivo MRI: advances and limitations" @default.
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- W1968479908 doi "https://doi.org/10.1038/nrn3085-c1" @default.
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