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- W1968482722 abstract "The purpose of the study was to compare the peripheral vascular effects of the calcium blocker nifedipine (NF) in normotensive Wistar Kyoto (WKY; n=25) rats and spontaneously hypertensive rats (SHR; n=28). Male eighteen week old animals were anesthetized with pentobarbital (50 mg/kg i.p.) and subjected to the radioactive microsphere technique for measurement of systemic and regional hemodynamics. While NF (30 ug/kg i.v. or 100 ug/kg i.v.) was effective in reducing resistance in all sampled vascular beds of SHR and WKY, it reduced renal vascular resistance to a greater extent in the SHR than in WKY (p < 0.025). The data suggested a similar strain-specific effect in the SHR coronary, stomach and brain vasculatures (0.12 < p < 0.16). By contrast, high dose NF had a preferential effect on the skeletal muscle vasculature of WKY (p < 0.025 for blood flow, p < 0.16 for resistance). The findings support the premise that each calcium blocker has unique regional effects that differ between SHR and WKY." @default.
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- W1968482722 date "1986-01-01" @default.
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- W1968482722 title "The Effects of Nifedipine on Regional Vascular Resistance and Blood Flow in the Spontaneously Hypertensive Rat" @default.
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- W1968482722 doi "https://doi.org/10.3109/10641968609044080" @default.
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