Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968483660> ?p ?o ?g. }
- W1968483660 endingPage "e101325" @default.
- W1968483660 startingPage "e101325" @default.
- W1968483660 abstract "Antiviral drugs are being used for therapeutic purposes against influenza illness in humans. However, antiviral-resistant variants often nullify the effectiveness of antivirals. Combined medications, as seen in the treatment of cancers and other infectious diseases, have been suggested as an option for the control of antiviral-resistant influenza viruses. Here, we evaluated the therapeutic value of combination therapy against oseltamivir-resistant 2009 pandemic influenza H1N1 virus infection in DBA/2 mice. Mice were treated for five days with favipiravir and peramivir starting 4 hours after lethal challenge. Compared with either monotherapy, combination therapy saved more mice from viral lethality and resulted in increased antiviral efficacy in the lungs of infected mice. Furthermore, the synergism between the two antivirals, which was consistent with the survival outcomes of combination therapy, indicated that favipiravir could serve as a critical agent of combination therapy for the control of oseltamivir-resistant strains. Our results provide new insight into the feasibility of favipiravir in combination therapy against oseltamivir-resistant influenza virus infection." @default.
- W1968483660 created "2016-06-24" @default.
- W1968483660 creator A5009082444 @default.
- W1968483660 creator A5016206203 @default.
- W1968483660 creator A5017462736 @default.
- W1968483660 creator A5022253992 @default.
- W1968483660 creator A5023069157 @default.
- W1968483660 creator A5023766436 @default.
- W1968483660 creator A5032888224 @default.
- W1968483660 creator A5039271899 @default.
- W1968483660 creator A5055816512 @default.
- W1968483660 creator A5059299202 @default.
- W1968483660 creator A5061875794 @default.
- W1968483660 creator A5065973461 @default.
- W1968483660 creator A5070164781 @default.
- W1968483660 creator A5071251829 @default.
- W1968483660 creator A5087601645 @default.
- W1968483660 date "2014-07-03" @default.
- W1968483660 modified "2023-10-16" @default.
- W1968483660 title "Combination Effects of Peramivir and Favipiravir against Oseltamivir-Resistant 2009 Pandemic Influenza A(H1N1) Infection in Mice" @default.
- W1968483660 cites W1537507249 @default.
- W1968483660 cites W1966104788 @default.
- W1968483660 cites W1981090797 @default.
- W1968483660 cites W1984845116 @default.
- W1968483660 cites W1988265465 @default.
- W1968483660 cites W1994937491 @default.
- W1968483660 cites W1999320428 @default.
- W1968483660 cites W2003719795 @default.
- W1968483660 cites W2004500875 @default.
- W1968483660 cites W2009428685 @default.
- W1968483660 cites W2015856821 @default.
- W1968483660 cites W2029589872 @default.
- W1968483660 cites W2029687992 @default.
- W1968483660 cites W2039561401 @default.
- W1968483660 cites W2040185402 @default.
- W1968483660 cites W2041051160 @default.
- W1968483660 cites W2043580251 @default.
- W1968483660 cites W2046094044 @default.
- W1968483660 cites W2050205112 @default.
- W1968483660 cites W2052287941 @default.
- W1968483660 cites W2058203122 @default.
- W1968483660 cites W2066295779 @default.
- W1968483660 cites W2070880385 @default.
- W1968483660 cites W2074127314 @default.
- W1968483660 cites W2074681797 @default.
- W1968483660 cites W2076253715 @default.
- W1968483660 cites W2080292807 @default.
- W1968483660 cites W2092528857 @default.
- W1968483660 cites W2093541604 @default.
- W1968483660 cites W2102368840 @default.
- W1968483660 cites W2104037238 @default.
- W1968483660 cites W2108367829 @default.
- W1968483660 cites W2114870626 @default.
- W1968483660 cites W2118192550 @default.
- W1968483660 cites W2125461332 @default.
- W1968483660 cites W2130608875 @default.
- W1968483660 cites W2130679801 @default.
- W1968483660 cites W2136685402 @default.
- W1968483660 cites W2138274210 @default.
- W1968483660 cites W2140566427 @default.
- W1968483660 cites W2143029493 @default.
- W1968483660 cites W2145733600 @default.
- W1968483660 cites W2151174475 @default.
- W1968483660 cites W2152580317 @default.
- W1968483660 cites W2165260654 @default.
- W1968483660 cites W2166596830 @default.
- W1968483660 cites W2167728159 @default.
- W1968483660 cites W89135872 @default.
- W1968483660 doi "https://doi.org/10.1371/journal.pone.0101325" @default.
- W1968483660 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4081560" @default.
- W1968483660 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24992479" @default.
- W1968483660 hasPublicationYear "2014" @default.
- W1968483660 type Work @default.
- W1968483660 sameAs 1968483660 @default.
- W1968483660 citedByCount "15" @default.
- W1968483660 countsByYear W19684836602014 @default.
- W1968483660 countsByYear W19684836602015 @default.
- W1968483660 countsByYear W19684836602016 @default.
- W1968483660 countsByYear W19684836602017 @default.
- W1968483660 countsByYear W19684836602019 @default.
- W1968483660 countsByYear W19684836602020 @default.
- W1968483660 countsByYear W19684836602022 @default.
- W1968483660 countsByYear W19684836602023 @default.
- W1968483660 crossrefType "journal-article" @default.
- W1968483660 hasAuthorship W1968483660A5009082444 @default.
- W1968483660 hasAuthorship W1968483660A5016206203 @default.
- W1968483660 hasAuthorship W1968483660A5017462736 @default.
- W1968483660 hasAuthorship W1968483660A5022253992 @default.
- W1968483660 hasAuthorship W1968483660A5023069157 @default.
- W1968483660 hasAuthorship W1968483660A5023766436 @default.
- W1968483660 hasAuthorship W1968483660A5032888224 @default.
- W1968483660 hasAuthorship W1968483660A5039271899 @default.
- W1968483660 hasAuthorship W1968483660A5055816512 @default.
- W1968483660 hasAuthorship W1968483660A5059299202 @default.
- W1968483660 hasAuthorship W1968483660A5061875794 @default.
- W1968483660 hasAuthorship W1968483660A5065973461 @default.
- W1968483660 hasAuthorship W1968483660A5070164781 @default.
- W1968483660 hasAuthorship W1968483660A5071251829 @default.