Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968487875> ?p ?o ?g. }
- W1968487875 endingPage "1308" @default.
- W1968487875 startingPage "1287" @default.
- W1968487875 abstract "Chemical genetics uses small molecules to modulate protein function and, in principle, has the potential to perturb any biochemical event in a complex cellular context. The application of chemical genetics to dissect biological processes has become an attractive alternative to mutagenesis screens due to its technical simplicity, inexpensive reagents, and low-startup costs. In vertebrates, only fish and amphibians are amenable to chemical genetic screens. Xenopus frogs share a long evolutionary history with mammals and so represent an excellent model to predict human biology. In this review, we discuss the lessons learned from chemical genetic studies carried out in zebrafish and Xenopus. We highlight how Xenopus can be employed as a convenient first-line animal model at various stages of the drug discovery and development process and comment on how they represent much-needed tools to bridge the gap between traditional in vitro and preclinical mammalian assays in biomedical research and drug development. Developmental Dynamics 238:1287–1308, 2009. © 2009 Wiley-Liss, Inc." @default.
- W1968487875 created "2016-06-24" @default.
- W1968487875 creator A5044905675 @default.
- W1968487875 creator A5079003288 @default.
- W1968487875 date "2009-06-01" @default.
- W1968487875 modified "2023-10-18" @default.
- W1968487875 title "Simple vertebrate models for chemical genetics and drug discovery screens: Lessons from zebrafish and<i>Xenopus</i>" @default.
- W1968487875 cites W1505060514 @default.
- W1968487875 cites W1507464447 @default.
- W1968487875 cites W1540649941 @default.
- W1968487875 cites W1552346480 @default.
- W1968487875 cites W1559457086 @default.
- W1968487875 cites W1562759933 @default.
- W1968487875 cites W1911978226 @default.
- W1968487875 cites W1947640509 @default.
- W1968487875 cites W1964378600 @default.
- W1968487875 cites W1965280193 @default.
- W1968487875 cites W1965671498 @default.
- W1968487875 cites W1968029095 @default.
- W1968487875 cites W1969892000 @default.
- W1968487875 cites W1972640343 @default.
- W1968487875 cites W1972999344 @default.
- W1968487875 cites W1976066719 @default.
- W1968487875 cites W1978216857 @default.
- W1968487875 cites W1984439372 @default.
- W1968487875 cites W1986724654 @default.
- W1968487875 cites W1990484548 @default.
- W1968487875 cites W1990545369 @default.
- W1968487875 cites W1990580731 @default.
- W1968487875 cites W1991506501 @default.
- W1968487875 cites W1992101966 @default.
- W1968487875 cites W1994279105 @default.
- W1968487875 cites W1995127906 @default.
- W1968487875 cites W1995827857 @default.
- W1968487875 cites W1996396912 @default.
- W1968487875 cites W1998748065 @default.
- W1968487875 cites W2000572318 @default.
- W1968487875 cites W2002442139 @default.
- W1968487875 cites W2002574403 @default.
- W1968487875 cites W2004473440 @default.
- W1968487875 cites W2008496580 @default.
- W1968487875 cites W2009766076 @default.
- W1968487875 cites W2011034991 @default.
- W1968487875 cites W2012836529 @default.
- W1968487875 cites W2013225537 @default.
- W1968487875 cites W2016046902 @default.
- W1968487875 cites W2019650000 @default.
- W1968487875 cites W2019751519 @default.
- W1968487875 cites W2021278551 @default.
- W1968487875 cites W2022962960 @default.
- W1968487875 cites W2029592424 @default.
- W1968487875 cites W2030837990 @default.
- W1968487875 cites W2031273426 @default.
- W1968487875 cites W2031296931 @default.
- W1968487875 cites W2033194415 @default.
- W1968487875 cites W2033280638 @default.
- W1968487875 cites W2034265209 @default.
- W1968487875 cites W2035192365 @default.
- W1968487875 cites W2035913145 @default.
- W1968487875 cites W2038185740 @default.
- W1968487875 cites W2039673745 @default.
- W1968487875 cites W2042592516 @default.
- W1968487875 cites W2043474702 @default.
- W1968487875 cites W2047642636 @default.
- W1968487875 cites W2050376918 @default.
- W1968487875 cites W2051777706 @default.
- W1968487875 cites W2052883905 @default.
- W1968487875 cites W2052907531 @default.
- W1968487875 cites W2052915489 @default.
- W1968487875 cites W2055280560 @default.
- W1968487875 cites W2055624323 @default.
- W1968487875 cites W2055992184 @default.
- W1968487875 cites W2057556321 @default.
- W1968487875 cites W2057638888 @default.
- W1968487875 cites W2057685263 @default.
- W1968487875 cites W2058207889 @default.
- W1968487875 cites W2060238037 @default.
- W1968487875 cites W2064813976 @default.
- W1968487875 cites W2065524522 @default.
- W1968487875 cites W2067183682 @default.
- W1968487875 cites W2067285199 @default.
- W1968487875 cites W2067658972 @default.
- W1968487875 cites W2069506489 @default.
- W1968487875 cites W2071359561 @default.
- W1968487875 cites W2071817831 @default.
- W1968487875 cites W2075244023 @default.
- W1968487875 cites W2077097535 @default.
- W1968487875 cites W2077731858 @default.
- W1968487875 cites W2078375403 @default.
- W1968487875 cites W2081365810 @default.
- W1968487875 cites W2081383642 @default.
- W1968487875 cites W2082152178 @default.
- W1968487875 cites W2082472219 @default.
- W1968487875 cites W2082624222 @default.
- W1968487875 cites W2086132135 @default.
- W1968487875 cites W2086145996 @default.
- W1968487875 cites W2087614968 @default.
- W1968487875 cites W2087867260 @default.