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- W1968491753 abstract "We read with great attention the article by Gil et al 1 Gil M Sala M Anguera I Chapinal O Cervantes M Guma J.R Segura F QT prolongation and torsades des pointes in patients infected with human immunodeficiency virus and treated with metadone. Am J Cardiol. 2003; 92: 995-997 Abstract Full Text Full Text PDF PubMed Scopus (96) Google Scholar on the QT prolongation and Torsades des pointes (TdP) in HIV-infected patients who received methadone. Although it has been reported that the daily methadone dose correlated positively with the QTc interval, 2 Krantz M.J Kutinsky I.B Robertson A.D Mehler P.S Dose-related effects of methadone on QT prolongation in a series of patients with torsade de pointes. Pharmacotherapy. 2003; 23: 802-805 Crossref PubMed Scopus (197) Google Scholar in HIV-infected patients, a QTc prolongation could be due to other causes that may enhance the effect of methadone on the ventricular potential duration, even at a lower dosage. A prolongation of QTc could be observed in patients with HIV-associated dilated cardiomyopathy as a consequence of myocarditis associated with fibrous degeneration of the conduction system 3 Barbaro G Di Lorenzo C Grisorio B Barbarini G Gruppo Italiano per lo Studio Cardiologico dei pazienti affetti da AIDS InvestigatorsCardiac involvement in the acquired immunodeficiency syndrome a multicenter clinical-pathological study. AIDS Res Hum Retroviruses. 1998; 14: 1071-1077 Crossref PubMed Scopus (166) Google Scholar or in patients with coronary artery disease as complication of higly active antiretroviral therapy-associated metabolic syndrome." @default.
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- W1968491753 date "2004-07-01" @default.
- W1968491753 modified "2023-09-27" @default.
- W1968491753 title "Methadone and QT prolongation in HIV-infected patients" @default.
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- W1968491753 doi "https://doi.org/10.1016/j.amjcard.2003.12.071" @default.
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