Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968492876> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W1968492876 endingPage "359" @default.
- W1968492876 startingPage "355" @default.
- W1968492876 abstract "D-Glycerate dehydrogenase (glyoxylate reductase) was partially purified from rat liver by anion- and cation-exchange chromatography. When assayed in the direction of D-glycerate or glycolate formation, the enzyme was inhibited by high (greater than or equal to 0.5 mM), unphysiological concentrations of hydroxypyruvate or glyoxylate much more potently in the presence of NADPH than in the presence of NADH. However, the dehydrogenase displayed a much greater affinity for NADPH (Km less than 1 microM) than for NADH (Km = 48-153 microM). Furthermore, NADP was over 1000-fold more potent than NAD in inhibiting the enzyme competitively with respect to NADH. NADP also inhibited the reaction competitively with respect to NADPH whereas NAD, at concentrations of up to 10 mM had no inhibitory effect. When measured by the formation of hydroxypyruvate from D-glycerate, the enzyme also displayed a much greater affinity for NADP than for NAD. These properties indicate that liver D-glycerate dehydrogenase functions physiologically as an NADPH-specific reductase. In agreement with this conclusion, the addition of hydroxypyruvate or glyoxylate to suspensions of rat hepatocytes stimulated the pentose-phosphate pathway. The coenzyme specificity of D-glycerate dehydrogenase is discussed in relation to the biochemical findings made in D-glyceric aciduria and in primary hyperoxaluria type II (L-glyceric aciduria)." @default.
- W1968492876 created "2016-06-24" @default.
- W1968492876 creator A5028909272 @default.
- W1968492876 creator A5043457314 @default.
- W1968492876 creator A5070312706 @default.
- W1968492876 date "1989-12-01" @default.
- W1968492876 modified "2023-10-17" @default.
- W1968492876 title "Coenzyme specificity of mammalian liver <scp>d</scp>‐glycerate dehydrogenase" @default.
- W1968492876 cites W122195215 @default.
- W1968492876 cites W1504961304 @default.
- W1968492876 cites W1541137308 @default.
- W1968492876 cites W1605194916 @default.
- W1968492876 cites W1647150274 @default.
- W1968492876 cites W1738677317 @default.
- W1968492876 cites W1775749144 @default.
- W1968492876 cites W1801184284 @default.
- W1968492876 cites W1975088963 @default.
- W1968492876 cites W1979511656 @default.
- W1968492876 cites W1991812607 @default.
- W1968492876 cites W2020737279 @default.
- W1968492876 cites W2038242952 @default.
- W1968492876 cites W2047038134 @default.
- W1968492876 cites W2055479342 @default.
- W1968492876 cites W2057754257 @default.
- W1968492876 cites W2058794804 @default.
- W1968492876 cites W2088000813 @default.
- W1968492876 cites W2090786222 @default.
- W1968492876 cites W2119054145 @default.
- W1968492876 cites W2324212983 @default.
- W1968492876 cites W2330377696 @default.
- W1968492876 cites W2425507839 @default.
- W1968492876 doi "https://doi.org/10.1111/j.1432-1033.1989.tb15216.x" @default.
- W1968492876 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2689175" @default.
- W1968492876 hasPublicationYear "1989" @default.
- W1968492876 type Work @default.
- W1968492876 sameAs 1968492876 @default.
- W1968492876 citedByCount "23" @default.
- W1968492876 countsByYear W19684928762016 @default.
- W1968492876 countsByYear W19684928762017 @default.
- W1968492876 countsByYear W19684928762020 @default.
- W1968492876 countsByYear W19684928762021 @default.
- W1968492876 countsByYear W19684928762023 @default.
- W1968492876 crossrefType "journal-article" @default.
- W1968492876 hasAuthorship W1968492876A5028909272 @default.
- W1968492876 hasAuthorship W1968492876A5043457314 @default.
- W1968492876 hasAuthorship W1968492876A5070312706 @default.
- W1968492876 hasBestOaLocation W19684928761 @default.
- W1968492876 hasConcept C134651460 @default.
- W1968492876 hasConcept C165267168 @default.
- W1968492876 hasConcept C181199279 @default.
- W1968492876 hasConcept C185592680 @default.
- W1968492876 hasConcept C197957613 @default.
- W1968492876 hasConcept C2776317432 @default.
- W1968492876 hasConcept C2777150147 @default.
- W1968492876 hasConcept C55493867 @default.
- W1968492876 hasConcept C75520062 @default.
- W1968492876 hasConceptScore W1968492876C134651460 @default.
- W1968492876 hasConceptScore W1968492876C165267168 @default.
- W1968492876 hasConceptScore W1968492876C181199279 @default.
- W1968492876 hasConceptScore W1968492876C185592680 @default.
- W1968492876 hasConceptScore W1968492876C197957613 @default.
- W1968492876 hasConceptScore W1968492876C2776317432 @default.
- W1968492876 hasConceptScore W1968492876C2777150147 @default.
- W1968492876 hasConceptScore W1968492876C55493867 @default.
- W1968492876 hasConceptScore W1968492876C75520062 @default.
- W1968492876 hasIssue "1-2" @default.
- W1968492876 hasLocation W19684928761 @default.
- W1968492876 hasLocation W19684928762 @default.
- W1968492876 hasOpenAccess W1968492876 @default.
- W1968492876 hasPrimaryLocation W19684928761 @default.
- W1968492876 hasRelatedWork W1565209129 @default.
- W1968492876 hasRelatedWork W2029462177 @default.
- W1968492876 hasRelatedWork W2037702679 @default.
- W1968492876 hasRelatedWork W2049048597 @default.
- W1968492876 hasRelatedWork W2053100519 @default.
- W1968492876 hasRelatedWork W2081009067 @default.
- W1968492876 hasRelatedWork W2103643682 @default.
- W1968492876 hasRelatedWork W2429842276 @default.
- W1968492876 hasRelatedWork W4206172903 @default.
- W1968492876 hasRelatedWork W4290012698 @default.
- W1968492876 hasVolume "186" @default.
- W1968492876 isParatext "false" @default.
- W1968492876 isRetracted "false" @default.
- W1968492876 magId "1968492876" @default.
- W1968492876 workType "article" @default.