Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968502562> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W1968502562 endingPage "194" @default.
- W1968502562 startingPage "188" @default.
- W1968502562 abstract "Hepatocyte transplantation is a conceptually attractive alternative to whole organ grafting for some inborn metabolic errors and for fulminant liver failure. However, studies of the immunogenicity of transplanted allogeneic hepatocytes have yielded contradictory results. In these experiments, the effect of purification and cryopreservation of the hepatocytes on the ability of these cells to engraft in the mouse allogeneic recipients without immunosuppression was studied. BALB/cByJ mouse crude (unpurified), modified (purified or cryopreserved), or dead (irradiated) hepatocyte preparations labeled with fluorescein dye CFSE were infused either into the portal vein or into the spleen parenchyma of the recipient CBA mice. A histological examination revealed normal appearance of engrafted modified hepatocytes with no signs of acute rejection up to 21 days posttransplant. Many of the intrasplenically implanted hepatocytes migrated into the hepatic sinusoids. The modified hepatocytes showed intact ultrastructural appearance 7 days after transplantation. The numbers of inoculated crude hepatocytes rapidly declined with signs of dense infiltration of mononuclear cells in the graft indicating destructive response. The fluorescence of dead hepatocytes was undetectable. These results suggest that reduced immunogenicity may be responsible for the longer survival time of inoculated, purified or cryopreserved hepatocytes with no adverse morphological effects." @default.
- W1968502562 created "2016-06-24" @default.
- W1968502562 creator A5045003773 @default.
- W1968502562 creator A5046124152 @default.
- W1968502562 creator A5051335951 @default.
- W1968502562 date "1999-06-23" @default.
- W1968502562 modified "2023-10-06" @default.
- W1968502562 title "Histological identification of purified and cryopreserved allogeneic hepatocytes following transplantation in a murine model without host immunosuppression" @default.
- W1968502562 cites W122047838 @default.
- W1968502562 cites W139966805 @default.
- W1968502562 cites W1490154674 @default.
- W1968502562 cites W1557393597 @default.
- W1968502562 cites W1967525977 @default.
- W1968502562 cites W1971614567 @default.
- W1968502562 cites W1973327484 @default.
- W1968502562 cites W1985861685 @default.
- W1968502562 cites W1998225382 @default.
- W1968502562 cites W2046421292 @default.
- W1968502562 cites W2049277799 @default.
- W1968502562 cites W2068028785 @default.
- W1968502562 cites W2076096492 @default.
- W1968502562 cites W2081510651 @default.
- W1968502562 cites W2088662117 @default.
- W1968502562 cites W2092653384 @default.
- W1968502562 cites W2112008182 @default.
- W1968502562 cites W2284172551 @default.
- W1968502562 cites W2410536878 @default.
- W1968502562 cites W2425648375 @default.
- W1968502562 cites W2502444184 @default.
- W1968502562 doi "https://doi.org/10.1007/s001470050209" @default.
- W1968502562 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10429956" @default.
- W1968502562 hasPublicationYear "1999" @default.
- W1968502562 type Work @default.
- W1968502562 sameAs 1968502562 @default.
- W1968502562 citedByCount "16" @default.
- W1968502562 countsByYear W19685025622012 @default.
- W1968502562 crossrefType "journal-article" @default.
- W1968502562 hasAuthorship W1968502562A5045003773 @default.
- W1968502562 hasAuthorship W1968502562A5046124152 @default.
- W1968502562 hasAuthorship W1968502562A5051335951 @default.
- W1968502562 hasConcept C141071460 @default.
- W1968502562 hasConcept C142724271 @default.
- W1968502562 hasConcept C16685009 @default.
- W1968502562 hasConcept C179933525 @default.
- W1968502562 hasConcept C196822366 @default.
- W1968502562 hasConcept C196843134 @default.
- W1968502562 hasConcept C202751555 @default.
- W1968502562 hasConcept C203014093 @default.
- W1968502562 hasConcept C2776200302 @default.
- W1968502562 hasConcept C2778252389 @default.
- W1968502562 hasConcept C2780252810 @default.
- W1968502562 hasConcept C2780868878 @default.
- W1968502562 hasConcept C2780931953 @default.
- W1968502562 hasConcept C2911091166 @default.
- W1968502562 hasConcept C55493867 @default.
- W1968502562 hasConcept C71924100 @default.
- W1968502562 hasConcept C86803240 @default.
- W1968502562 hasConcept C8891405 @default.
- W1968502562 hasConcept C95444343 @default.
- W1968502562 hasConceptScore W1968502562C141071460 @default.
- W1968502562 hasConceptScore W1968502562C142724271 @default.
- W1968502562 hasConceptScore W1968502562C16685009 @default.
- W1968502562 hasConceptScore W1968502562C179933525 @default.
- W1968502562 hasConceptScore W1968502562C196822366 @default.
- W1968502562 hasConceptScore W1968502562C196843134 @default.
- W1968502562 hasConceptScore W1968502562C202751555 @default.
- W1968502562 hasConceptScore W1968502562C203014093 @default.
- W1968502562 hasConceptScore W1968502562C2776200302 @default.
- W1968502562 hasConceptScore W1968502562C2778252389 @default.
- W1968502562 hasConceptScore W1968502562C2780252810 @default.
- W1968502562 hasConceptScore W1968502562C2780868878 @default.
- W1968502562 hasConceptScore W1968502562C2780931953 @default.
- W1968502562 hasConceptScore W1968502562C2911091166 @default.
- W1968502562 hasConceptScore W1968502562C55493867 @default.
- W1968502562 hasConceptScore W1968502562C71924100 @default.
- W1968502562 hasConceptScore W1968502562C86803240 @default.
- W1968502562 hasConceptScore W1968502562C8891405 @default.
- W1968502562 hasConceptScore W1968502562C95444343 @default.
- W1968502562 hasIssue "3" @default.
- W1968502562 hasLocation W19685025621 @default.
- W1968502562 hasLocation W19685025622 @default.
- W1968502562 hasOpenAccess W1968502562 @default.
- W1968502562 hasPrimaryLocation W19685025621 @default.
- W1968502562 hasRelatedWork W1971291175 @default.
- W1968502562 hasRelatedWork W1978874879 @default.
- W1968502562 hasRelatedWork W2076775565 @default.
- W1968502562 hasRelatedWork W2112008182 @default.
- W1968502562 hasRelatedWork W2138758116 @default.
- W1968502562 hasRelatedWork W2169258235 @default.
- W1968502562 hasRelatedWork W2358712394 @default.
- W1968502562 hasRelatedWork W2502444184 @default.
- W1968502562 hasRelatedWork W3031263852 @default.
- W1968502562 hasRelatedWork W3031440537 @default.
- W1968502562 hasVolume "12" @default.
- W1968502562 isParatext "false" @default.
- W1968502562 isRetracted "false" @default.
- W1968502562 magId "1968502562" @default.
- W1968502562 workType "article" @default.