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- W1968510701 abstract "Abstract Propylthiouracil has been shown experimentally to protect against alcohol-induced hepatocellular necrosis in hypoxic conditions. An earlier, short-term study of patients with alcoholism and liver disease indicated clinical improvement with propylthiouracil, but the effect on mortality could not be assessed. In the present study, we investigated the effect of propylthiouracil on mortality in patients with alcoholic liver disease in a long-term, double-blind, randomized clinical trial involving 310 compliant patients who received propylthiouracil (n = 157) or placebo (n = 153) for a maximum of two years. There were no differences between the two groups in demographic and clinical characteristics and biopsy-confirmed diagnoses at randomization, or in daily urinary alcohol levels during the study. The cumulative dropout rate over two years was not significantly different (propylthiouracil group, 0.68; placebo group, 0.60). The group receiving propylthiouracil (300 mg per day) had a cumulative mortali..." @default.
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- W1968510701 date "1988-04-01" @default.
- W1968510701 modified "2023-10-18" @default.
- W1968510701 title "LONG-TERM TREATMENT OF ALCOHOLIC LIVER DISEASE WITH PROPYLTHIOURACIL" @default.
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- W1968510701 doi "https://doi.org/10.1016/s0140-6736(88)91649-2" @default.
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