FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968511036> ?p ?o ?g. }

• W1968511036 endingPage "159" @default.
• W1968511036 startingPage "147" @default.
• W1968511036 abstract "Abstract The development of remyelinating strategies designed to enhance recruitment and differentiation of endogenous precursor cells available to a site of demyelination in the adult spinal cord will require a fundamental understanding of the potential for adult spinal cord precursor cells to remyelinate as well as an insight into epigenetic cues that regulate their mobilization and differentiation. The ability of embryonic and postnatal neural precursor cell transplants to remyelinate the adult central nervous system is well documented, while no transplantation studies to date have examined the remyelinating potential of adult spinal‐cord‐derived oligodendrocyte precursor cells (adult OPCs). In the present study, we demonstrate that, when transplanted subacutely into spinal ethidium bromide/X‐irradiated (EB‐X) lesions, adult OPCs display a limited capacity for oligodendrocyte remyelination. Interestingly, the glia‐free environment of EB lesions promotes engrafted adult OPCs to differentiate primarily into cells with immunophenotypic and ultrastructural characteristics of myelinating Schwann cells (SCs). Astrocytes modulate this potential, as evidenced by the demonstration that SC‐like differentiation is blocked when adult OPCs are co‐transplanted with astrocytes. We further show that inhibition of bone morphogenetic protein (BMP) signaling through noggin overexpression by engrafted adult OPCs is sufficient to block SC‐like differentiation within EB‐X lesions. Present data suggest that the macroglial‐free environment of acute EB lesions in the ventrolateral funiculus is inhibitory to adult spinal cord‐derived OPC differentiation into remyelinating oligodendrocytes, while the presence of BMPs and absence of noggin promotes SC‐like differentiation, thereby unmasking a surprising lineage fate for these cells. © 2006 Wiley‐Liss, Inc." @default.
• W1968511036 created "2016-06-24" @default.
• W1968511036 creator A5011792461 @default.
• W1968511036 creator A5017106522 @default.
• W1968511036 creator A5037759389 @default.
• W1968511036 creator A5059970716 @default.
• W1968511036 creator A5069737327 @default.
• W1968511036 creator A5078310984 @default.
• W1968511036 creator A5079134143 @default.
• W1968511036 creator A5079136793 @default.
• W1968511036 creator A5090876424 @default.
• W1968511036 date "2006-06-22" @default.
• W1968511036 modified "2023-10-13" @default.
• W1968511036 title "Schwann cell-like differentiation by adult oligodendrocyte precursor cells following engraftment into the demyelinated spinal cord is BMP-dependent" @default.
• W1968511036 cites W1485371658 @default.
• W1968511036 cites W1536744532 @default.
• W1968511036 cites W1904944436 @default.
• W1968511036 cites W1967493950 @default.
• W1968511036 cites W1969765196 @default.
• W1968511036 cites W1971675257 @default.
• W1968511036 cites W1972045793 @default.
• W1968511036 cites W1973972775 @default.
• W1968511036 cites W1978125793 @default.
• W1968511036 cites W1978143545 @default.
• W1968511036 cites W1981371990 @default.
• W1968511036 cites W1983909073 @default.
• W1968511036 cites W1985286185 @default.
• W1968511036 cites W1993374418 @default.
• W1968511036 cites W1994185969 @default.
• W1968511036 cites W1999039175 @default.
• W1968511036 cites W2003037534 @default.
• W1968511036 cites W2005578607 @default.
• W1968511036 cites W2006761965 @default.
• W1968511036 cites W2012998384 @default.
• W1968511036 cites W2015037358 @default.
• W1968511036 cites W2017655089 @default.
• W1968511036 cites W2018462517 @default.
• W1968511036 cites W2021742478 @default.
• W1968511036 cites W2024825981 @default.
• W1968511036 cites W2025201512 @default.
• W1968511036 cites W2027167625 @default.
• W1968511036 cites W2033322963 @default.
• W1968511036 cites W2037716466 @default.
• W1968511036 cites W2040022455 @default.
• W1968511036 cites W2041010883 @default.
• W1968511036 cites W2043505498 @default.
• W1968511036 cites W2044807965 @default.
• W1968511036 cites W2045277155 @default.
• W1968511036 cites W2050989030 @default.
• W1968511036 cites W2054973570 @default.
• W1968511036 cites W2059994807 @default.
• W1968511036 cites W2062219279 @default.
• W1968511036 cites W2079517713 @default.
• W1968511036 cites W2081440662 @default.
• W1968511036 cites W2084532990 @default.
• W1968511036 cites W2087614658 @default.
• W1968511036 cites W2091857269 @default.
• W1968511036 cites W2093867725 @default.
• W1968511036 cites W2096262211 @default.
• W1968511036 cites W2097619939 @default.
• W1968511036 cites W2099225289 @default.
• W1968511036 cites W2099270578 @default.
• W1968511036 cites W2113964043 @default.
• W1968511036 cites W2117523148 @default.
• W1968511036 cites W2119318470 @default.
• W1968511036 cites W2119691340 @default.
• W1968511036 cites W2120964352 @default.
• W1968511036 cites W2123016546 @default.
• W1968511036 cites W2149592881 @default.
• W1968511036 cites W2150569013 @default.
• W1968511036 cites W2162008350 @default.
• W1968511036 cites W2170828389 @default.
• W1968511036 cites W2414992565 @default.
• W1968511036 cites W2416383789 @default.
• W1968511036 cites W4213096412 @default.
• W1968511036 doi "https://doi.org/10.1002/glia.20369" @default.
• W1968511036 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2813493" @default.
• W1968511036 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16921543" @default.
• W1968511036 hasPublicationYear "2006" @default.
• W1968511036 type Work @default.
• W1968511036 sameAs 1968511036 @default.
• W1968511036 citedByCount "69" @default.
• W1968511036 countsByYear W19685110362012 @default.
• W1968511036 countsByYear W19685110362013 @default.
• W1968511036 countsByYear W19685110362014 @default.
• W1968511036 countsByYear W19685110362015 @default.
• W1968511036 countsByYear W19685110362016 @default.
• W1968511036 countsByYear W19685110362017 @default.
• W1968511036 countsByYear W19685110362018 @default.
• W1968511036 countsByYear W19685110362019 @default.
• W1968511036 countsByYear W19685110362020 @default.
• W1968511036 countsByYear W19685110362021 @default.
• W1968511036 countsByYear W19685110362022 @default.
• W1968511036 countsByYear W19685110362023 @default.
• W1968511036 crossrefType "journal-article" @default.
• W1968511036 hasAuthorship W1968511036A5011792461 @default.
• W1968511036 hasAuthorship W1968511036A5017106522 @default.
• W1968511036 hasAuthorship W1968511036A5037759389 @default.

• next