Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968511350> ?p ?o ?g. }
- W1968511350 endingPage "1512" @default.
- W1968511350 startingPage "1499" @default.
- W1968511350 abstract "Signaling via estrogen receptor (ER) occurs by interacting with many proteins. Nuclear interactome analysis of ERα in an embryo implantation model revealed the association of chicken tumor virus no. 10 regulator of kinase like (CrkL) with ERα, which was further validated by mammalian two-hybrid assay as well as coimmunoprecipitation and colocalization. Mutation in LPALL motif of CrkL disrupts the ERα-CrkL interaction and its transactivation potential, thereby suggesting that the interaction is mediated via its single ER binding motif, Leu-Pro-Ala-Leu-Leu (LXXLL) motif in the sarcoma homology (SH)2 domain. CrkL deletion constructs of SH2 domain target to the nucleus due to presence of nuclear localization signal. Interestingly, the SH2-SH3 (N terminal) construct shows an increased transactivation potential like CrkI. Weak interaction capability of mutated ERα-Y538F with CrkL validates that CrkL interacts with ERα via its YDLL motif at Tyr 541. In an attempt to understand the physiological relevance of this association, we investigated the impact on cell proliferation using a cancer model, because events associated in the process of pregnancy and cancer are analogous. Also, overexpression of CrkL is frequently associated with tumorigenesis. However, its significance in hormone-regulated cancers still remains obscure. Here, we demonstrate that association of ERα and CrkL directly enhances the tumorigenic potential of CrkL, thus pointing to its role in cell proliferation. In human endometrial cancers, we observed a strong association between ERα and CrkL levels. Thus, the molecular signaling set off by ERα and CrkL association may have a central role in pregnancy and cancer, two events which share parallels in growth, invasion, and immune tolerance." @default.
- W1968511350 created "2016-06-24" @default.
- W1968511350 creator A5001917596 @default.
- W1968511350 creator A5011550577 @default.
- W1968511350 creator A5077483531 @default.
- W1968511350 creator A5079422661 @default.
- W1968511350 date "2011-09-01" @default.
- W1968511350 modified "2023-10-14" @default.
- W1968511350 title "CrkL is a Co-Activator of Estrogen Receptor α That Enhances Tumorigenic Potential in Cancer" @default.
- W1968511350 cites W1501286679 @default.
- W1968511350 cites W1514878396 @default.
- W1968511350 cites W1606012461 @default.
- W1968511350 cites W1613446635 @default.
- W1968511350 cites W1848404107 @default.
- W1968511350 cites W1966475217 @default.
- W1968511350 cites W1968558132 @default.
- W1968511350 cites W1974900814 @default.
- W1968511350 cites W1976989643 @default.
- W1968511350 cites W1977685162 @default.
- W1968511350 cites W1977703157 @default.
- W1968511350 cites W1990503476 @default.
- W1968511350 cites W1994935017 @default.
- W1968511350 cites W2005581728 @default.
- W1968511350 cites W2011944892 @default.
- W1968511350 cites W2017753377 @default.
- W1968511350 cites W2017759076 @default.
- W1968511350 cites W2022008947 @default.
- W1968511350 cites W2024102536 @default.
- W1968511350 cites W2028545666 @default.
- W1968511350 cites W2038217619 @default.
- W1968511350 cites W2051519140 @default.
- W1968511350 cites W2054267961 @default.
- W1968511350 cites W2054420189 @default.
- W1968511350 cites W2057808719 @default.
- W1968511350 cites W2058450187 @default.
- W1968511350 cites W2058862223 @default.
- W1968511350 cites W2060213573 @default.
- W1968511350 cites W2069229776 @default.
- W1968511350 cites W2069755909 @default.
- W1968511350 cites W2070907292 @default.
- W1968511350 cites W2077994082 @default.
- W1968511350 cites W2089646327 @default.
- W1968511350 cites W2095687368 @default.
- W1968511350 cites W2097317987 @default.
- W1968511350 cites W2100837269 @default.
- W1968511350 cites W2103779104 @default.
- W1968511350 cites W2103934675 @default.
- W1968511350 cites W2123020057 @default.
- W1968511350 cites W2133603533 @default.
- W1968511350 cites W2141686420 @default.
- W1968511350 cites W2149532912 @default.
- W1968511350 cites W2152229306 @default.
- W1968511350 doi "https://doi.org/10.1210/me.2011-0008" @default.
- W1968511350 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5417229" @default.
- W1968511350 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21700719" @default.
- W1968511350 hasPublicationYear "2011" @default.
- W1968511350 type Work @default.
- W1968511350 sameAs 1968511350 @default.
- W1968511350 citedByCount "11" @default.
- W1968511350 countsByYear W19685113502013 @default.
- W1968511350 countsByYear W19685113502014 @default.
- W1968511350 countsByYear W19685113502015 @default.
- W1968511350 countsByYear W19685113502016 @default.
- W1968511350 countsByYear W19685113502021 @default.
- W1968511350 countsByYear W19685113502023 @default.
- W1968511350 crossrefType "journal-article" @default.
- W1968511350 hasAuthorship W1968511350A5001917596 @default.
- W1968511350 hasAuthorship W1968511350A5011550577 @default.
- W1968511350 hasAuthorship W1968511350A5077483531 @default.
- W1968511350 hasAuthorship W1968511350A5079422661 @default.
- W1968511350 hasBestOaLocation W19685113501 @default.
- W1968511350 hasConcept C104317684 @default.
- W1968511350 hasConcept C121608353 @default.
- W1968511350 hasConcept C1292079 @default.
- W1968511350 hasConcept C170493617 @default.
- W1968511350 hasConcept C172313692 @default.
- W1968511350 hasConcept C173396325 @default.
- W1968511350 hasConcept C174510640 @default.
- W1968511350 hasConcept C502942594 @default.
- W1968511350 hasConcept C530470458 @default.
- W1968511350 hasConcept C54355233 @default.
- W1968511350 hasConcept C555283112 @default.
- W1968511350 hasConcept C84606932 @default.
- W1968511350 hasConcept C86339819 @default.
- W1968511350 hasConcept C86803240 @default.
- W1968511350 hasConcept C95444343 @default.
- W1968511350 hasConceptScore W1968511350C104317684 @default.
- W1968511350 hasConceptScore W1968511350C121608353 @default.
- W1968511350 hasConceptScore W1968511350C1292079 @default.
- W1968511350 hasConceptScore W1968511350C170493617 @default.
- W1968511350 hasConceptScore W1968511350C172313692 @default.
- W1968511350 hasConceptScore W1968511350C173396325 @default.
- W1968511350 hasConceptScore W1968511350C174510640 @default.
- W1968511350 hasConceptScore W1968511350C502942594 @default.
- W1968511350 hasConceptScore W1968511350C530470458 @default.
- W1968511350 hasConceptScore W1968511350C54355233 @default.
- W1968511350 hasConceptScore W1968511350C555283112 @default.
- W1968511350 hasConceptScore W1968511350C84606932 @default.