Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968521301> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W1968521301 abstract "We hypothesized that virulence levels of Escherichia coli isolates causing pediatric urinary tract infections differ according to severity of infection and also among various uropathies known to contribute to pediatric urinary tract infections. We evaluated these relationships using in vitro cytokine interleukin-6 elicitation.E. coli isolates were cultured from children presenting with urinary tract infections. In vitro cytokine (interleukin-6) elicitation was quantified for each isolate and the bacteria were grouped according to type of infection and underlying uropathy (neurogenic bladder, nonneurogenic bowel and bladder dysfunction, primary vesicoureteral reflux, no underlying etiology).A total of 40 E. coli isolates were collected from children with a mean age of 61.5 months (range 1 to 204). Mean level of in vitro cytokine elicitation from febrile urinary tract infection producing E. coli was significantly lower than for nonfebrile strains (p = 0.01). The interleukin-6 response to E. coli in the neurogenic bladder group was also significantly higher than in the vesicoureteral reflux (p = 0.01) and no underlying etiology groups (p = 0.02).In vitro interleukin-6 elicitation, an established marker to determine bacterial virulence, correlates inversely with clinical urinary tract infection severity. Less virulent, high cytokine producing E. coli were more likely to cause cystitis and were more commonly found in patients with neurogenic bladder and nonneurogenic bowel and bladder dysfunction, whereas higher virulence isolates were more likely to produce febrile urinary tract infections and to affect children with primary vesicoureteral reflux and no underlying etiology. These findings suggest that bacteria of different virulence levels may be responsible for differences in severity of pediatric urinary tract infections and may vary among different underlying uropathies." @default.
- W1968521301 created "2016-06-24" @default.
- W1968521301 creator A5008462752 @default.
- W1968521301 creator A5014517800 @default.
- W1968521301 creator A5023986813 @default.
- W1968521301 creator A5043416343 @default.
- W1968521301 creator A5058260095 @default.
- W1968521301 creator A5059596986 @default.
- W1968521301 date "2012-07-01" @default.
- W1968521301 modified "2023-09-25" @default.
- W1968521301 title "Relationship Among Bacterial Virulence, Bladder Dysfunction, Vesicoureteral Reflux and Patterns of Urinary Tract Infection in Children" @default.
- W1968521301 cites W111614474 @default.
- W1968521301 cites W1904816508 @default.
- W1968521301 cites W1965332276 @default.
- W1968521301 cites W1966581513 @default.
- W1968521301 cites W1970012260 @default.
- W1968521301 cites W1990845730 @default.
- W1968521301 cites W2001346590 @default.
- W1968521301 cites W2011896213 @default.
- W1968521301 cites W2013735659 @default.
- W1968521301 cites W2044377521 @default.
- W1968521301 cites W2076019861 @default.
- W1968521301 cites W2086808983 @default.
- W1968521301 cites W2090889747 @default.
- W1968521301 cites W2128478149 @default.
- W1968521301 cites W2150670322 @default.
- W1968521301 cites W2153435059 @default.
- W1968521301 cites W2157796076 @default.
- W1968521301 cites W2166419456 @default.
- W1968521301 cites W2462791972 @default.
- W1968521301 cites W4234376416 @default.
- W1968521301 doi "https://doi.org/10.1016/j.juro.2012.03.025" @default.
- W1968521301 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22595065" @default.
- W1968521301 hasPublicationYear "2012" @default.
- W1968521301 type Work @default.
- W1968521301 sameAs 1968521301 @default.
- W1968521301 citedByCount "10" @default.
- W1968521301 countsByYear W19685213012013 @default.
- W1968521301 countsByYear W19685213012015 @default.
- W1968521301 countsByYear W19685213012016 @default.
- W1968521301 countsByYear W19685213012017 @default.
- W1968521301 countsByYear W19685213012018 @default.
- W1968521301 crossrefType "journal-article" @default.
- W1968521301 hasAuthorship W1968521301A5008462752 @default.
- W1968521301 hasAuthorship W1968521301A5014517800 @default.
- W1968521301 hasAuthorship W1968521301A5023986813 @default.
- W1968521301 hasAuthorship W1968521301A5043416343 @default.
- W1968521301 hasAuthorship W1968521301A5058260095 @default.
- W1968521301 hasAuthorship W1968521301A5059596986 @default.
- W1968521301 hasConcept C104317684 @default.
- W1968521301 hasConcept C126322002 @default.
- W1968521301 hasConcept C126894567 @default.
- W1968521301 hasConcept C137627325 @default.
- W1968521301 hasConcept C203014093 @default.
- W1968521301 hasConcept C2776664737 @default.
- W1968521301 hasConcept C2777609623 @default.
- W1968521301 hasConcept C2779134260 @default.
- W1968521301 hasConcept C43270747 @default.
- W1968521301 hasConcept C55493867 @default.
- W1968521301 hasConcept C60987743 @default.
- W1968521301 hasConcept C71924100 @default.
- W1968521301 hasConcept C77411442 @default.
- W1968521301 hasConcept C86803240 @default.
- W1968521301 hasConcept C90924648 @default.
- W1968521301 hasConceptScore W1968521301C104317684 @default.
- W1968521301 hasConceptScore W1968521301C126322002 @default.
- W1968521301 hasConceptScore W1968521301C126894567 @default.
- W1968521301 hasConceptScore W1968521301C137627325 @default.
- W1968521301 hasConceptScore W1968521301C203014093 @default.
- W1968521301 hasConceptScore W1968521301C2776664737 @default.
- W1968521301 hasConceptScore W1968521301C2777609623 @default.
- W1968521301 hasConceptScore W1968521301C2779134260 @default.
- W1968521301 hasConceptScore W1968521301C43270747 @default.
- W1968521301 hasConceptScore W1968521301C55493867 @default.
- W1968521301 hasConceptScore W1968521301C60987743 @default.
- W1968521301 hasConceptScore W1968521301C71924100 @default.
- W1968521301 hasConceptScore W1968521301C77411442 @default.
- W1968521301 hasConceptScore W1968521301C86803240 @default.
- W1968521301 hasConceptScore W1968521301C90924648 @default.
- W1968521301 hasLocation W19685213011 @default.
- W1968521301 hasLocation W19685213012 @default.
- W1968521301 hasOpenAccess W1968521301 @default.
- W1968521301 hasPrimaryLocation W19685213011 @default.
- W1968521301 hasRelatedWork W1963930217 @default.
- W1968521301 hasRelatedWork W1999909508 @default.
- W1968521301 hasRelatedWork W2011008355 @default.
- W1968521301 hasRelatedWork W2019761442 @default.
- W1968521301 hasRelatedWork W2020919552 @default.
- W1968521301 hasRelatedWork W2023831807 @default.
- W1968521301 hasRelatedWork W2071193357 @default.
- W1968521301 hasRelatedWork W2090129853 @default.
- W1968521301 hasRelatedWork W2400606793 @default.
- W1968521301 hasRelatedWork W2410587865 @default.
- W1968521301 isParatext "false" @default.
- W1968521301 isRetracted "false" @default.
- W1968521301 magId "1968521301" @default.
- W1968521301 workType "article" @default.