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- W1968521617 abstract "IRITA, K., SAKAI, H., ISOBE, H., YAMAKAWA, M., NAWATA, H. and YOSHITAKE, J. The Effect of OP 2507, a Stable Analogue of Prostacyclin, on Hep G2 Exposed to Hypoxia. Tohoku J. Exp. Med., 1990, 162 (2), 177-182 - We developed a model for screening drugs to reduce ischemic liver damage using Hep G2, a hepatoblastoma cell line, and examined the effect of OP 2507, a stable analogue of prostacyclin, on hypoxic cell damage. Hypoxic exposure of the cells was done for 16hr in an air-tight chamber which was placed inside an incubator and was purged with 5% CO2/95% N2. Adding OP 2507 (0.01-10ng/ml) to the incubation medium during hypoxic exposure reduced mitochondrial damage estimated by MTT-reducing activity, while it failed to inhibit lactate accumulation in the medium. OP 2507 seems to be a good candidate for improving the preservation of liver allografts." @default.
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- W1968521617 date "1990-01-01" @default.
- W1968521617 modified "2023-10-05" @default.
- W1968521617 title "The effect of OP 2507, a stable analogue of prostacyclin, on Hep G2 exposed to hypoxia." @default.
- W1968521617 doi "https://doi.org/10.1620/tjem.162.177" @default.
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