Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968523385> ?p ?o ?g. }
- W1968523385 endingPage "2517" @default.
- W1968523385 startingPage "2507" @default.
- W1968523385 abstract "A general increase in protein synthesis and a specific increase in the synthesis of growth-promoting proteins are necessary for mitogenesis. Regulation of protein synthesis, as well as preferential translation of some mRNAs coding for growth promoting proteins (e.g. cyclin D1), involves the essential protein synthesis initiation factor eIF-4E. This factor is induced by various oncoproteins, and, when overexpressed, it can transform cultured cells. In this report we explore the roles of eIF-4E in human neoplastic disorders of the colon and in the regulation of general and specific protein synthesis. We find that eIF-4E is increased in colon adenomas and carcinomas, and this increase is accompanied in most but not all cases by elevation of cyclin D1 levels. While general protein synthesis is increased by eIF-4E overexpression in cultured cells, only a small proportion of proteins is preferentially up-regulated by eIF-4E, as revealed by two-dimensional gel electrophoresis. These results are consistent with the view that eIF-4E plays a role in carcinogenesis by increasing general protein synthesis and by preferentially upregulating a subset of putative growth promoting proteins. Our results, taken together with the recent findings that c-myc transcription is negatively regulated by APC and our earlier data on transcriptional activation of eIF-4E expression by c-Myc suggest that eIF-4E is a downstream target of the APC/β-catenin/Tcf-4 pathway, and is strongly involved in colon tumorigenesis." @default.
- W1968523385 created "2016-06-24" @default.
- W1968523385 creator A5007631856 @default.
- W1968523385 creator A5017579714 @default.
- W1968523385 creator A5044660766 @default.
- W1968523385 creator A5061083766 @default.
- W1968523385 creator A5075877090 @default.
- W1968523385 creator A5085640743 @default.
- W1968523385 date "1999-04-15" @default.
- W1968523385 modified "2023-10-17" @default.
- W1968523385 title "Upregulation of protein synthesis initiation factor eIF-4E is an early event during colon carcinogenesis" @default.
- W1968523385 cites W1569698611 @default.
- W1968523385 cites W1581341594 @default.
- W1968523385 cites W1606423922 @default.
- W1968523385 cites W1867818493 @default.
- W1968523385 cites W1874612019 @default.
- W1968523385 cites W1893291537 @default.
- W1968523385 cites W1966275499 @default.
- W1968523385 cites W1967137553 @default.
- W1968523385 cites W1970918239 @default.
- W1968523385 cites W1974559924 @default.
- W1968523385 cites W1974770298 @default.
- W1968523385 cites W1981524094 @default.
- W1968523385 cites W1982715030 @default.
- W1968523385 cites W1983061888 @default.
- W1968523385 cites W1989830594 @default.
- W1968523385 cites W1997806157 @default.
- W1968523385 cites W1999330214 @default.
- W1968523385 cites W1999694266 @default.
- W1968523385 cites W2000360985 @default.
- W1968523385 cites W2002404925 @default.
- W1968523385 cites W2013151136 @default.
- W1968523385 cites W2016693266 @default.
- W1968523385 cites W2020998971 @default.
- W1968523385 cites W2029080338 @default.
- W1968523385 cites W2030039393 @default.
- W1968523385 cites W2031900820 @default.
- W1968523385 cites W2051815560 @default.
- W1968523385 cites W2054414484 @default.
- W1968523385 cites W2078049733 @default.
- W1968523385 cites W2082722418 @default.
- W1968523385 cites W2093531978 @default.
- W1968523385 cites W2098412103 @default.
- W1968523385 cites W2142505369 @default.
- W1968523385 cites W2154214377 @default.
- W1968523385 cites W2154739953 @default.
- W1968523385 cites W2168370162 @default.
- W1968523385 cites W4233934059 @default.
- W1968523385 cites W4236776658 @default.
- W1968523385 doi "https://doi.org/10.1038/sj.onc.1202563" @default.
- W1968523385 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10229202" @default.
- W1968523385 hasPublicationYear "1999" @default.
- W1968523385 type Work @default.
- W1968523385 sameAs 1968523385 @default.
- W1968523385 citedByCount "168" @default.
- W1968523385 countsByYear W19685233852012 @default.
- W1968523385 countsByYear W19685233852013 @default.
- W1968523385 countsByYear W19685233852014 @default.
- W1968523385 countsByYear W19685233852015 @default.
- W1968523385 countsByYear W19685233852016 @default.
- W1968523385 countsByYear W19685233852017 @default.
- W1968523385 countsByYear W19685233852018 @default.
- W1968523385 countsByYear W19685233852019 @default.
- W1968523385 countsByYear W19685233852020 @default.
- W1968523385 countsByYear W19685233852021 @default.
- W1968523385 countsByYear W19685233852022 @default.
- W1968523385 countsByYear W19685233852023 @default.
- W1968523385 crossrefType "journal-article" @default.
- W1968523385 hasAuthorship W1968523385A5007631856 @default.
- W1968523385 hasAuthorship W1968523385A5017579714 @default.
- W1968523385 hasAuthorship W1968523385A5044660766 @default.
- W1968523385 hasAuthorship W1968523385A5061083766 @default.
- W1968523385 hasAuthorship W1968523385A5075877090 @default.
- W1968523385 hasAuthorship W1968523385A5085640743 @default.
- W1968523385 hasBestOaLocation W19685233851 @default.
- W1968523385 hasConcept C104317684 @default.
- W1968523385 hasConcept C105580179 @default.
- W1968523385 hasConcept C127561419 @default.
- W1968523385 hasConcept C1491633281 @default.
- W1968523385 hasConcept C149364088 @default.
- W1968523385 hasConcept C153911025 @default.
- W1968523385 hasConcept C199835354 @default.
- W1968523385 hasConcept C29537977 @default.
- W1968523385 hasConcept C3675279 @default.
- W1968523385 hasConcept C502942594 @default.
- W1968523385 hasConcept C55493867 @default.
- W1968523385 hasConcept C555283112 @default.
- W1968523385 hasConcept C62493599 @default.
- W1968523385 hasConcept C86339819 @default.
- W1968523385 hasConcept C86803240 @default.
- W1968523385 hasConcept C95444343 @default.
- W1968523385 hasConceptScore W1968523385C104317684 @default.
- W1968523385 hasConceptScore W1968523385C105580179 @default.
- W1968523385 hasConceptScore W1968523385C127561419 @default.
- W1968523385 hasConceptScore W1968523385C1491633281 @default.
- W1968523385 hasConceptScore W1968523385C149364088 @default.
- W1968523385 hasConceptScore W1968523385C153911025 @default.
- W1968523385 hasConceptScore W1968523385C199835354 @default.