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• W1968524664 abstract "Influenza is a major burden to public health. Due to high mutation rates and selection pressure, mutant viruses emerge which are resistant to currently used antiviral drugs. Therefore, there is a need for the development of novel classes of antiviral drugs that suffer less from the emergence of resistant viruses. Antiviral drugs based on collectin-like surfactant protein D (SP-D) may fulfil these requirements. Especially porcine SP-D displays strong antiviral activity to influenza A viruses. In the present study the antiviral activity of recombinant porcine SP-D was investigated in ex vivo cultures of respiratory tract tissue infected with human influenza A virus of the H3N2 subtype. Porcine SP-D has antiviral activity in these test systems. It is suggested that porcine SP-D may be used as a venue to develop a novel class of antiviral drugs." @default.
• W1968524664 created "2016-06-24" @default.
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• W1968524664 date "2014-03-01" @default.
• W1968524664 modified "2023-10-01" @default.
• W1968524664 title "Recombinant porcine surfactant protein D inhibits influenza A virus replication ex vivo" @default.
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• W1968524664 doi "https://doi.org/10.1016/j.virusres.2013.12.032" @default.
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