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• W1968527449 abstract "Rapid developments in the food applications of silver nanomaterials (Ag-NMs) have resulted in concerns related to the risk of overexposure of human blood. We investigated the effect of size and aspect ratio of Ag-NMs on rheological characteristics of human erythrocytes, including hemolysis, deformability, aggregation, and morphological changes. Red blood cells (RBCs) were exposed to two different sizes of spherical particles (d ∼ 30 nm or 100 nm) or nanowires (d ∼ 40 nm, l–2 μm in length) at a range of concentrations and incubation times. The concentrations of Ag-NMs were carefully chosen to avoid any hemorheological alteration due to hemolysis. Rheological properties were measured using microfluidic-laser diffractometry and aggregometry. RBC deformability apparently decreased after treatment with a low concentration of Ag-NPs for a short exposure time. However, RBC aggregation was significantly altered after treatment with a low concentration of either Ag-NWs or large Ag-NPs compared to small Ag-NPs. Additional experiments with Ag ions confirmed that the observed rheological changes were mainly caused by the Ag-NMs rather than the Ag ions. These hemorheological findings provide a better understanding of the interaction between RBCs and Ag-NMs and will help in assessing the risk of nanomaterial toxicity in blood." @default.
• W1968527449 created "2016-06-24" @default.
• W1968527449 creator A5027381296 @default.
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• W1968527449 date "2014-05-01" @default.
• W1968527449 modified "2023-10-04" @default.
• W1968527449 title "Toxic effects of silver nanoparticles and nanowires on erythrocyte rheology" @default.
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• W1968527449 doi "https://doi.org/10.1016/j.fct.2014.02.006" @default.
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